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Yoko Ozawa, MD, PhD

Biography_Yoko_Ozawa_MD_PhD

Expertises:

Surgical and Medical Retina, Regenerative Medicine

Current Affiliation:

Fujita Health University Haneda Clinic

Professor, Department of Clinical Regenerative Medicine, Fujita Health University

Publications

  1. Ozawa Y, Onozato N, Togawa H, Shimmura S. Associations between retinal thickness and background factors in eyes without retinal diseases. Sci Rep. 2025;15(1):21796. doi:10.1038/s41598-025-06863-4

  2. Mushiga Y, Nagai N, Ozawa Y. Associations between serum lipid levels and the macular retinal volumes in patients with diabetes. PLoS One. 2025;20(6):e0325500. doi:10.1371/journal.pone.0325500

  3. Sugisawa T, Gomi F, Harada Y, Imaizumi H, Aoki S, Miki A, Kishi M, Yamauchi T, Nagasato D, Ozawa Y, Haruta M, Kato N, Matsubara H, Yasukawa T, Kato A, Terasaki H, Hirano T, Iesato Y, Tsujinaka H, Murakami T, Mitamura Y, Wakuta M, Kimura K, Shimura M. Factors that contribute to loss to follow-up in the medium term after initiation of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in Japanese patients. PLoS One. 2025;20(6):e0325963. doi:10.1371/journal.pone.0325963

  4. Nagai N, Matsubara H, Terasaki H, Hirano T, Kato A, Miki A, Hirai H, Murao F, Imaizumi H, Gomi F, Mitamura Y, Ogata N, Kusuhara S, Yasukawa T, Murata T, Sakamoto T, Kondo M, Shinoda H, Ozawa Y. Extent of Complete Retinal Pigment Epithelial and Outer Retinal Atrophy with Foveal Center Involvement is Associated with Visual Acuity. Ophthalmol Sci. 2025;5(1):100612. doi:10.1016/j.xops.2024.100612

  5. Ozawa Y, Yoshihara K, Mezghani M, Pierzchala P, Nikodem M, Barbier S, Nomoto M, Aitoku Y. Recent daily life burdens associated with neovascular age-related macular degeneration involve difficulties in use of electronic devices. Sci Rep. 2024;14(1):14181. doi:10.1038/s41598-024-65089-y

  6. Sonoda K, Komatsu M, Ozawa Y, Yamamoto H, Kamijo Y. Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study. Biomedicines. 2024;12(4):849. doi:10.3390/biomedicines12040849

  7. Nagai N, Mushiga Y, Ozawa Y. Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels. Sci Rep. 2023;13(1):22570. doi:10.1038/s41598-023-50132-1

  8. Tezuka T, Shibata M, Hanaoka H, Izawa Y, Kikuchi T, Akino K, Ozawa Y, Saito M, Kaneko Y, Nakahara J, Takizawa T. Systemic lupus erythematosus mimicking retinal migraine: a case report. Cephalalgia. 2023;43(12):03331024231219477. doi:10.1177/03331024231219477

  9. Nagai N, Mushiga Y, Ozawa Y. Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography. Sci Rep. 2023;13(1):13809. doi:10.1038/s41598-023-40686-5

  10. Sasaki M, Yuki K, Hanyuda A, Yamagishi K, Motomura K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Sawada N, Negishi K, Tsubota K, Tsugane S, Iso H. Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Sci Rep. 2023;13(1):12903. doi:10.1038/s41598-023-39734-x

  11. Ozawa Y, Ohgami K, Sasaki K, Hirano K, Sunaya T. Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration. Sci Rep. 2023;13(1):10597. doi:10.1038/s41598-023-37584-1

  12. Nagai N, Mushiga Y, Ozawa Y. Retinal Pigment Epithelial Abnormality and Choroidal Large Vascular Flow Imbalance Are Associated with Choriocapillaris Flow Deficits in Age-Related Macular Degeneration in Fellow Eyes. J Clin Med. 2023;12(4):1360. doi:10.3390/jcm12041360

  13. Yasukawa T, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Yamagishi K, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H. Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population: JPHC-NEXT Eye Study. Transl Vis Sci Technol. 2023;12(1):3. doi:10.1167/tvst.12.1.3

  14. Mushiga Y, Nagai N, Ozawa Y. Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics. Sci Rep. 2022;12(1):17457. doi:10.1038/s41598-022-21117-3

  15. Yasukawa T, Hanyuda A, Yamagishi K, Yuki K, Uchino M, Ozawa Y, Sasaki M, Tsubota K, Sawada N, Negishi K, Tsugane S, Iso H. Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study. Sci Rep. 2022;12(1):17493. doi:10.1038/s41598-022-22301-1

  16. Aichi R, Nagai N, Ohkoshi K, Ozawa Y. Impact of Treating Age-Related Macular Degeneration before Visual Function Is Impaired. J Clin Med. 2022;11(19):5726. doi:10.3390/jcm11195726

  17. Harada N, Nagai N, Mushiga Y, Ozawa Y. Choriocapillaris Flow Imbalance in Fellow Eyes in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2022;63(9):13. doi:10.1167/iovs.63.9.13

  18. Ozawa Y, Toda E, Homma K, Osada H, Nagai N, Tsubota K, Okano H. Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa. Cells. 2022;11(9):1497. doi:10.3390/cells11091497

  19. Ofuji Y, Katada Y, Tomita Y, Nagai N, Sonobe H, Watanabe K, Shinoda H, Ozawa Y, Negishi K, Tsubota K, Kurihara T. Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy. Life (Basel). 2022;12(4):542. doi:10.3390/life12040542

  20. Takei T, Nagai N, Ohkoshi K, Ozawa Y. Arm-to-retina time predicts visual outcome of anti-vascular endothelial growth factor treatment for macular edema due to central retinal vein occlusion. Sci Rep. 2022;12(1):2194. doi:10.1038/s41598-022-06281-w

  21. Mushiga Y, Komoto T, Nagai N, Ozawa Y. Effects of intraocular treatments for Epstein-Barr virus (EBV) retinitis: A case report. Medicine (Baltimore). 2021;100(48):e28101. doi:10.1097/MD.0000000000028101

  22. Akino K, Nagai N, Watanabe K, Ban N, Kurihara T, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane. Br J Ophthalmol. 2021;105(12):1683-1687. doi:10.1136/bjophthalmol-2020-317478

  23. Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y. Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion. J Clin Med. 2021;10(17):3944. doi:10.3390/jcm10173944

  24. Nakamura K, Honda R, Soeda S, Nagai N, Takahashi O, Kadonosono K, Ozawa Y. Factors associated with achieving intraocular pressure lower than 15 mmHg by Trabectome surgery in primary open-angle glaucoma. Sci Rep. 2021;11(1):14308. doi:10.1038/s41598-021-93711-w

  25. Mendoza NAG, Homma K, Osada H, Toda E, Ban N, Nagai N, Negishi K, Tsubota K, Ozawa Y. Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina. Antioxidants (Basel). 2021;10(7):1147. doi:10.3390/antiox10071147

  26. Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, Ozawa Y. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Cell Death Dis. 2021;12(5):458. doi:10.1038/s41419-021-03741-5

  27. Shinojima A, Ozawa Y, Uchida A, Nagai N, Shinoda H, Kurihara T, Suzuki M, Minami S, Negishi K, Tsubota K. Assessment of Hypofluorescent Foci on Late-Phase Indocyanine Green Angiography in Central Serous Chorioretinopathy. J Clin Med. 2021;10(10):2178. doi:10.3390/jcm10102178

  28. Aketa N, Uchino M, Kawashima M, Uchino Y, Yuki K, Ozawa Y, Sasaki M, Yamagishi K, Sawada N, Tsugane S, Tsubota K, Iso H. Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study. Sci Rep. 2021;11(1):6366. doi:10.1038/s41598-021-85617-4

  29. Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y. Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium. Redox Biol. 2021;41:101921. doi:10.1016/j.redox.2021.101921

  30. Minowa Y, Ohkoshi K, Ozawa Y. Subthreshold Laser Treatment for Serous Retinal Detachment Associated with Tilted Disc Syndrome. Case Rep Ophthalmol. 2021;12(3):978-986. doi:10.1159/000520570

  31. Mori T, Kikuchi T, Koh M, Koda Y, Yamazaki R, Sakurai M, Tomita Y, Ozawa Y, Kohashi S, Abe R, Saburi M, Kato J. Cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation under cytomegalovirus antigenemia-guided active screening. Bone Marrow Transplant. 2021;56(6):1266-1271. doi:10.1038/s41409-020-01176-8

  32. Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman NA, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y. Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Commun Biol. 2020;3(1):767. doi:10.1038/s42003-020-01483-2

  33. Sato M, Minami S, Nagai N, Suzuki M, Kurihara T, Shinojima A, Sonobe H, Akino K, Ban N, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Association between axial length and choroidal thickness in early age-related macular degeneration. PLoS One. 2020;15(10):e0240357. doi:10.1371/journal.pone.0240357

  34. Ozawa Y. Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration. Redox Biol. 2020;37:101779. doi:10.1016/j.redox.2020.101779

  35. Asato T, Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y. Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment. Lasers Med Sci. 2021;36(2):469-471. doi:10.1007/s10103-020-03133-9

  36. Mushiga Y, Minami S, Uchida A, Nagai N, Suzuki M, Kurihara T, Sonobe H, Ban N, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome. J Clin Med. 2020;9(8):2394. doi:10.3390/jcm9082394

  37. Minami S, Nagai N, Suzuki M, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Ocular and Systemic Effects of Antioxidative Supplement Use in Young and Healthy Adults: Real-World Cross-Sectional Data. Antioxidants (Basel). 2020;9(6):487. doi:10.3390/antiox9060487

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  39. Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y. The Area and Number of Intraretinal Cystoid Spaces Predict the Visual Outcome after Ranibizumab Monotherapy in Diabetic Macular Edema. J Clin Med. 2020;9(5):1391. doi:10.3390/jcm9051391

  40. Nagai N, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y. Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration. J Clin Med. 2020;9(5):1347. doi:10.3390/jcm9051347

  41. Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y. Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina. Nutrients. 2020;12(4):888. doi:10.3390/nu12040888

  42. Suzumura A, Kaneko H, Funahashi Y, Takayama K, Nagaya M, Ito S, Okuno T, Hirakata T, Nonobe N, Kataoka K, Shimizu H, Namba R, Yamada K, Ye F, Ozawa Y, Yokomizo T, Terasaki H. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy. Diabetes. 2020;69(4):724-735. doi:10.2337/db19-0550

  43. Hanyuda A, Sawada N, Yuki K, Uchino M, Ozawa Y, Sasaki M, Yamagishi K, Iso H, Tsubota K, Tsugane S. Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study. Sci Rep. 2020;10(1):5355. doi:10.1038/s41598-020-62135-3

  44. Kawashima H, Ozawa Y, Toda E, Homma K, Osada H, Narimatsu T, Nagai N, Tsubota K. Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator. FASEB J. 2020;34(4):5016-5026. doi:10.1096/fj.201902387RR

  45. Ozawa Y, Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Uehara T, Kawakami S, Fujita A, Fujinaga Y, Oguchi K, Kawa S, Hanaoka M. A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis. Nagoya J Med Sci. 2020;82(1):101-111. doi:10.18999/nagjms.82.1.101

  46. Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H. Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study. Sci Rep. 2020;10(1):779. doi:10.1038/s41598-019-57260-7

  47. Saito S, Tanaka R, Sasaki T, Aoki S, Yasuhara R, Nakayama Y, Nagai T, Sonobe H, Ozawa Y, Kubo A. Subclinical hypopigmentation of the skin and hair in a Japanese patient with Hermansky-Pudlak syndrome type 3. J Dermatol. 2020;47(1):e18-e20. doi:10.1111/1346-8138.15118

  48. Suzuki M, Nagai N, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy. Graefes Arch Clin Exp Ophthalmol. 2020;258(1):49-56. doi:10.1007/s00417-019-04495-9

  49. Minami S, Shinoda H, Shigeno Y, Nagai N, Kurihara T, Watanabe K, Sonobe H, Takagi H, Tsubota K, Ozawa Y. Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy. Sci Rep. 2019;9:19056. doi:10.1038/s41598-019-55544-6

  50. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Takagi H, Tsubota K, Ozawa Y. Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults. Sci Rep. 2019;9:18119. doi:10.1038/s41598-019-54606-z

  51. Ozawa Y, Shinoda H, Nagai N, Tsubota K. Dynamic changes in neural retinal images during the development of a lamellar macular hole: A case report. Medicine (Baltimore). 2019;98(49):e18297. doi:10.1097/MD.0000000000018297

  52. Ozawa Y, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K. Aquaporin 4 Suppresses Neural Hyperactivity and Synaptic Fatigue and Fine-Tunes Neurotransmission to Regulate Visual Function in the Mouse Retina. Mol Neurobiol. 2019;56(12):8124-8135. doi:10.1007/s12035-019-01661-2

  53. Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K. High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study. J Clin Med. 2019;8(11):1788. doi:10.3390/jcm8111788

  54. Okamoto T, Kawashima H, Osada H, Toda E, Homma K, Nagai N, Imai Y, Tsubota K, Ozawa Y. Dietary Spirulina Supplementation Protects Visual Function From Photostress by Suppressing Retinal Neurodegeneration in Mice. Transl Vis Sci Technol. 2019;8(6):20. doi:10.1167/tvst.8.6.20

  55. Mimura R, Mori K, Torii H, Nagai N, Suzuki M, Minami S, Ozawa Y, Kurihara T, Tsubota K. Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma. J Clin Med. 2019;8(10):1505. doi:10.3390/jcm8101505

  56. Nagai N, Suzuki M, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy. Sci Rep. 2019;9:11389. doi:10.1038/s41598-019-47738-9

  57. Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. QD laser eyewear as a visual field aid in a visual field defect model. Sci Rep. 2019;9:1010. doi:10.1038/s41598-018-37744-8

  58. Hayashi I, Shinoda H, Nagaia N, Tsubota K, Ozawa Y. Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: A case report. Medicine (Baltimore). 2019;98(4):e14230. doi:10.1097/MD.0000000000014230

  59. Kawashima H, Nagai N, Shinoda H, Tsubota K, Ozawa Y. Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. Medicine (Baltimore). 2018;97(17):e0321. doi:10.1097/MD.0000000000010321

  60. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y. Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline. Sci Rep. 2018;8:58. doi:10.1038/s41598-017-18255-4

  61. Ozawa Y, Shigeno Y, Nagai N, Suzuki M, Kurihara T, Minami S, Hirano E, Shinoda H, Kobayashi S, Tsubota K. Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration. BMC Ophthalmol. 2017;17:161. doi:10.1186/s12886-017-0557-5

  62. Osada H, Okamoto T, Kawashima H, Toda E, Miyake S, Nagai N, Kobayashi S, Tsubota K, Ozawa Y. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One. 2017;12(6):e0178627. doi:10.1371/journal.pone.0178627

  63. Nagai N, Ibuki M, Shinoda H, Kameyama K, Tsubota K, Ozawa Y. Maculopapular rash after intravitreal injection of an antivascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report. Medicine (Baltimore). 2017;96(21):e6965. doi:10.1097/MD.0000000000006965

  64. Sato S, Shinoda H, Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Tomita Y, Iyama C, Minami S, Yuki K, Tsubota K, Ozawa Y. Predictive factors of better outcomes by monotherapy of an antivascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice. Medicine (Baltimore). 2017;96(16):e6459. doi:10.1097/MD.0000000000006459

  65. Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K. Novel RP1L1 Variants and Genotype-Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2016;57(11):4837-4846. doi:10.1167/iovs.16-19670

  66. Nagai N, Ohta Y, Izumi-Nagai K, Shinoda H, Tsubota K, Ozawa Y. Sneddon's syndrome with optic disc macroaneurysm and macular edema successfully treated with subtenon steroid injection. Acta Ophthalmol. 2016;94(6):e517-e519. doi:10.1111/aos.12909

  67. Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y. Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy With Single or Multiple Polyps: REPLY. Am J Ophthalmol. 2016;169:295-296. doi:10.1016/j.ajo.2016.06.018

  68. Kamoshita M, Toda E, Osada H, Narimatsu T, Kobayashi S, Tsubota K, Ozawa Y. Lutein acts via multiple antioxidant pathways in the photo-stressed retina. Sci Rep. 2016;6:30226. doi:10.1038/srep30226

  69. Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y. Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment. Sci Rep. 2016;6:29619. doi:10.1038/srep29619

  70. Kamoshita M, Fujinami K, Toda E, Tsubota K, Ozawa Y. Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation. BMC Neurosci. 2016;17:32. doi:10.1186/s12868-016-0268-5

  71. Masaki Y, Kawabata H, Takai K, Kojima M, Tsukamoto N, Ishigaki Y, Kurose N, Ide M, Murakami J, Nara K, Yamamoto H, Ozawa Y, Takahashi H, Miura K, Miyauchi T, Yoshida S, Momoi A, Awano N, Ikushima S, Ohta Y, Furuta N, Fujimoto S, Kawanami H, Sakai T, Kawanami T, Fujita Y, Fukushima T, Nakamura S, Kinoshita T, Aoki S. Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version. Int J Hematol. 2016;103(6):686-692. doi:10.1007/s12185-016-1979-1

  72. Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y. Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy With Single or Multiple Polyps. Am J Ophthalmol. 2016;166:52-59. doi:10.1016/j.ajo.2016.03.024

  73. Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y. Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration. J Biol Chem. 2016;291(14):7373-7385. doi:10.1074/jbc.M115.710186

  74. Okamoto T, Ozawa Y, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K. The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation. PLoS One. 2016;11(1):e0146517. doi:10.1371/journal.pone.0146517

  75. Tomita Y, Nagai N, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y. Functional Visual Acuity in Age-Related Macular Degeneration. Optom Vis Sci. 2016;93(1):70-76. doi:10.1097/OPX.0000000000000755

  76. Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y. Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling. Sci Rep. 2015;5:13256. doi:10.1038/srep13256

  77. Ozawa Y, Koto T, Shinoda H, Tsubota K. Vision Loss by Central Retinal Vein Occlusion After Kaatsu Training: A Case Report. Medicine (Baltimore). 2015;94(36):e1515. doi:10.1097/MD.0000000000001515

  78. Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y. ASSOCIATION OF MACULAR PIGMENT OPTICAL DENSITY WITH SERUM CONCENTRATION OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEALTHY ADULTS. Retina. 2015;35(4):820-826. doi:10.1097/IAE.0000000000000382

  79. Yotsukura-Tsutsui E, Koto T, Tsubota K, Ozawa Y. Predisposing factors for intraocular lens dislocation treated by pars plana vitrectomy: Involvement of atopic dermatitis. J Cataract Refract Surg. 2015;41(4):892-894. doi:10.1016/j.jcrs.2014.12.047

  80. Narimatsu T, Negishi K, Miyake S, Hirasawa M, Osada H, Kurihara T, Tsubota K, Ozawa Y. Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo. Exp Eye Res. 2015;132:48-51. doi:10.1016/j.exer.2015.01.003

  81. Ono T, Yuki K, Awano-Tanabe S, Fukagawa K, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Driving Self-restriction and Motor Vehicle Collision Occurrence in Glaucoma. Optom Vis Sci. 2015;92(3):357-364. doi:10.1097/OPX.0000000000000493

  82. Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Robson AG, Holder GE, Allikmets R, Michaelides M, Moore AT. Clinical and Molecular Characteristics of Childhood-Onset Stargardt Disease. Ophthalmology. 2015;122(2):326-334. doi:10.1016/j.ophtha.2014.08.012

  83. Kamoshita M, Matsumoto Y, Nishimura K, Katono Y, Murata M, Ozawa Y, Shimmura S, Tsubota K. Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin. J Infect Chemother. 2015;21(1-2):141-143. doi:10.1016/j.jiac.2014.08.019

  84. Ono T, Yuki K, Asaoka R, Kouyama K, Abe T, Tanabe S, Fukagawa K, Uchino M, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Glaucomatous Visual Field Defect Severity and the Prevalence of Motor Vehicle Collisions in Japanese: A Hospital/Clinic-Based Cross-Sectional Study. J Ophthalmol. 2015;2015:497067. doi:10.1155/2015/497067

  85. Nagai N, Kubota S, Tsubota K, Ozawa Y. Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types. J Nutr Biochem. 2014;25(11):1218-1225. doi:10.1016/j.jnutbio.2014.05.015

  86. Okamoto T, Shinoda H, Kurihara T, Nagai N, Tsubota K, Ozawa Y. Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy. BMC Ophthalmol. 2014;14:114. doi:10.1186/1471-2415-14-114

  87. Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K, Ozawa Y. Predictive factors for non-response to intravitreal ranibizumab treatment in age-related macular degeneration. Br J Ophthalmol. 2014;98(9):1186-1191. doi:10.1136/bjophthalmol-2013-304670

  88. Narimatsu T, Ozawa Y, Miyake S, Kubota S, Yuki K, Nagai N, Tsubota K. Biological effects of blocking blue and other visible light on the mouse retina. Clin Experiment Ophthalmol. 2014;42(6):555-563. doi:10.1111/ceo.12253

  89. Sasaki M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Wong TY, Ozawa Y. Early Signs of Exudative Age-Related Macular Degeneration in Asians. Optom Vis Sci. 2014;91(8):849-853. doi:10.1097/OPX.0000000000000317

  90. Kamoshita M, Ozawa Y, Kubota S, Miyake S, Tsuda C, Nagai N, Yuki K, Shimmura S, Umezawa K, Tsubota K. AMPK-NF-κB Axis in the Photoreceptor Disorder during Retinal Inflammation. PLoS One. 2014;9(7):e103013. doi:10.1371/journal.pone.0103013

  91. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain. 2014;7:45. doi:10.1186/1756-6606-7-45

  92. Narimatsu T, Ozawa Y, Miyake S, Nagai N, Tsubota K. Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina. Free Radic Biol Med. 2014;71:176-185. doi:10.1016/j.freeradbiomed.2014.03.020

  93. Miyake S, Kobayashi S, Tsubota K, Ozawa Y. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line. Biochem Biophys Res Commun. 2014;446(2):535-540. doi:10.1016/j.bbrc.2014.02.135

  94. Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Wang JJ, Ozawa Y. Association of Serum Lipids With Macular Thickness and Volume in Type 2 Diabetes Without Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2014;55(3):1749-1753. doi:10.1167/iovs.13-13035

  95. Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y. VITRECTOMY FOR MYOPIC FOVEOSCHISIS WITH INTERNAL LIMITING MEMBRANE PEELING AND NO GAS TAMPONADE. Retina. 2014;34(3):455-460. doi:10.1097/IAE.0b013e3182a0e477

  96. Uchida A, Miwa M, Shinoda H, Koto T, Nagai N, Mochimaru H, Tomita Y, Sasaki M, Ikeda K, Tsubota K, Ozawa Y. Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks. J Ophthalmol. 2014;2014:187929. doi:10.1155/2014/187929

  97. Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S. Atp6ap2/(Pro)renin Receptor Interacts with Par3 as a Cell Polarity Determinant Required for Laminar Formation during Retinal Development in Mice. J Neurosci. 2013;33(49):19341-19351. doi:10.1523/JNEUROSCI.1362-13.2013

  98. Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013;48(11):1212-1217. doi:10.1016/j.exger.2013.04.010

  99. Yuki K, Tanabe S, Kouyama K, Fukagawa K, Uchino M, Shimoyama M, Ozeki N, Shiba D, Ozawa Y, Abe T, Tsubota K. The Association Between Visual Field Defect Severity and Fear of Falling in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2013;54(12):7739-7745. doi:10.1167/iovs.13-12079

  100. Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Webster AR, Moore AT, Allikmets R, Michaelides M. ABCA4 Gene Screening by Next-Generation Sequencing in a British Cohort. Invest Ophthalmol Vis Sci. 2013;54(10):6662-6674. doi:10.1167/iovs.13-12570

  101. Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol. 2013;48(10):1096-1100. doi:10.1016/j.exger.2013.04.002

  102. Yuki K, Yoshida T, Miyake S, Tsubota K, Ozawa Y. Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-D-aspartate-induced cytotoxicity. Exp Eye Res. 2013;115:230-238. doi:10.1016/j.exer.2013.07.002

  103. Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y. Detection of early visual impairment in patients with epiretinal membrane. Acta Ophthalmol. 2013;91(5):e353-e357. doi:10.1111/aos.12060

  104. Yoshikawa N, Noda K, Ozawa Y, Mashima Y, Ishida S. Blockade for vascular adhesion protein-1 suppresses pathological neovascularization in oxygen-induced retinopathy. Acta Ophthalmol. 2013;91(5):e409-e410. doi:10.1111/aos.12128

  105. Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y. Molecular characteristics of four Japanese cases with KCNV2 retinopathy: Report of novel disease-causing variants. Mol Vis. 2013;19:1580-1590.

  106. Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K. Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice. Invest Ophthalmol Vis Sci. 2013;54(7):4555-4562. doi:10.1167/iovs.12-11572

  107. Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K. Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease. PLoS One. 2013;8(6):e64724. doi:10.1371/journal.pone.0064724

  108. Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Serum Vascular Adhesion Protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes. J Diabetes Complications. 2013;27(2):162-166. doi:10.1016/j.jdiacomp.2012.09.001

  109. Ozawa Y, Yuki K, Yamagishi R, Tsubota K, Aihara M. Renin-angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells. Jpn J Ophthalmol. 2013;57(1):126-132. doi:10.1007/s10384-012-0204-x

  110. Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K. Presence and Physiologic Function of the Renin-Angiotensin System in Mouse Lacrimal Gland. Invest Ophthalmol Vis Sci. 2012;53(9):5416-5425. doi:10.1167/iovs.12-9891

  111. Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S. Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2012;53(7):4055-4062. doi:10.1167/iovs.12-9857

  112. Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y. Biological role of lutein in the light-induced retinal degeneration. J Nutr Biochem. 2012;23(5):423-429. doi:10.1016/j.jnutbio.2011.01.006

  113. Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization. Mol Vis. 2012;18:593-600.

  114. Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol. 2012;363(1):106-114. doi:10.1016/j.ydbio.2011.12.027

  115. Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y. Use of Micronutrient Supplement for Preventing Advanced Age-Related Macular Degeneration in Japan. Arch Ophthalmol. 2012;130(2):254-255. doi:10.1001/archopthalmol.2011.1368

  116. Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Lab Invest. 2012;92(1):102-109. doi:10.1038/labinvest.2011.132

  117. Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K. Neuroprotective Effects of Lutein in the Retina. Curr Pharm Des. 2012;18(1):51-56. doi:10.2174/138161212798919101

  118. Suzuki M, Ozawa Y, Kubota S, Hirasawa M, Miyake S, Noda K, Tsubota K, Kadonosono K, Ishida S. Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor. J Neuroinflammation. 2011;8:176. doi:10.1186/1742-2094-8-176

  119. Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K. Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation. Invest Ophthalmol Vis Sci. 2011;52(12):9142-9148. doi:10.1167/iovs.11-8041

  120. Yuki K, Ozawa Y, Yoshida T, Kurihara T, Hirasawa M, Ozeki N, Shiba D, Noda K, Ishida S, Tsubota K. Retinal Ganglion Cell Loss in Superoxide Dismutase 1 Deficiency. Invest Ophthalmol Vis Sci. 2011;52(7):4143-4150. doi:10.1167/iovs.10-6294

  121. Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, Inoue M, Ogawa Y, Tsubota K, Ishida S. Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. Mol Vis. 2011;17:1222-1230.

  122. Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y. Clinical Findings in a Choroideremia Patient Who Underwent Vitrectomy for Retinal Detachment Associated with Macular Hole. Jpn J Ophthalmol. 2011;55(2):169-171. doi:10.1007/s10384-010-0911-0

  123. Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal Alkali-Burn Model. Invest Ophthalmol Vis Sci. 2011;52(1):427-433. doi:10.1167/iovs.10-6167

  124. Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K. Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model. Exp Diabetes Res. 2011:108328. doi:10.1155/2011/108328

  125. Ozawa Y, Kurihara T, Tsubota K, Okano H. Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection. J Ophthalmol. 2011;2011:506137. doi:10.1155/2011/506137

  126. Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation. Am J Pathol. 2010;177(4):1725-1731. doi:10.2353/ajpath.2010.100098

  127. Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S. Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. Mol Vis. 2010;16:1382-1388.

  128. Tomita Y, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy. Jpn J Ophthalmol. 2010;54(4):366-368. doi:10.1007/s10384-010-0823-z

  129. Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010;137(9):1563-1571. doi:10.1242/dev.049015

  130. Ozawa Y, Kubota S, Narimatsu T, Yuki K, Koto T, Sasaki M, Tsubota K. Retinal Aging and Sirtuins. Ophthalmic Res. 2010;44(3):199-203. doi:10.1159/000316484

  131. Sugisaka E, Shinoda K, Sano RY, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Mechanism of Visual Sensations Experienced during Pars Plana Vitrectomy under Retrobulbar Anesthesia. Ophthalmologica. 2010;224(2):103-108. doi:10.1159/000235858

  132. Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K. Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis. 2009;15:2751-2761.

  133. Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K. Involvement of Hyaluronan and Its Receptor CD44 with Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2009;50(9):4410-4415. doi:10.1167/iovs.08-3044

  134. Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-κB Activation. Invest Ophthalmol Vis Sci. 2009;50(7):3512-3519. doi:10.1167/iovs.08-2666

  135. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin Receptor-Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation. Diabetes. 2009;58(7):1625-1633. doi:10.2337/db08-0254

  136. Hirasawa M, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection. Jpn J Ophthalmol. 2009;53(3):279-281. doi:10.1007/s10384-009-0665-8

  137. Sasaki M, Ozawa Y, Kurihara T, Noda K, Imamura Y, Kobayashi S, Ishida S, Tsubota K. Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation. Invest Ophthalmol Vis Sci. 2009;50(3):1433-1439. doi:10.1167/iovs.08-2493

  138. Susaki K, Kaneko J, Yamano Y, Nakamura K, Inami W, Yoshikawa T, Ozawa Y, Shibata S, Matsuzaki O, Okano H, Chiba C. Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp Eye Res. 2009;88(3):347-355. doi:10.1016/j.exer.2008.06.019

  139. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin Receptor Promotes Choroidal Neovascularization by Activating Its Signal Transduction and Tissue Renin-Angiotensin System. Am J Pathol. 2008;173(6):1911-1918. doi:10.2353/ajpath.2008.080457

  140. Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H. Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. J Biol Chem. 2008;283(36):24561-24570. doi:10.1074/jbc.M802238200

  141. Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y, Ishida S. Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina. Diabetes. 2008;57(8):2191-2198. doi:10.2337/db07-1281

  142. Hashizume K, Hirasawa M, Imamura Y, Noda S, Shimizu T, Shinoda K, Kurihara T, Noda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K. Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice. Am J Pathol. 2008;172(5):1325-1331. doi:10.2353/ajpath.2008.070730

  143. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci. 2008;49(4):1679-1685. doi:10.1167/iovs.07-1426

  144. Shinoda H, Shinoda K, Satofuka S, Imamura Y, Ozawa Y, Ishida S, Inoue M. Visual recovery after vitrectomy for macular hole using 25-gauge instruments. Acta Ophthalmol. 2008;86(2):151-155. doi:10.1111/j.1600-0420.2007.01000.x

  145. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S, Oike Y, Ishida S. Macular pigment lutein is antiinflammatory in preventing Choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2007;27(12):2555-2562. doi:10.1161/ATVBAHA.107.151431

  146. Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T, Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S. Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2. Invest Ophthalmol Vis Sci. 2007;48(10):4795-4801. doi:10.1167/iovs.07-0425

  147. Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(9):4328-4334. doi:10.1167/iovs.06-1148

  148. Nagai N, Izumi-Nagai K, Oike Y, Koto T, Satofuka S, Ozawa Y, Yamashiro K, Inoue M, Tsubota K, Umezawa K, Ishida S. Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-κB pathway. Invest Ophthalmol Vis Sci. 2007;48(9):4342-4350. doi:10.1167/iovs.06-1473

  149. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia. Am J Ophthalmol. 2007;144(2):245-251. doi:10.1016/j.ajo.2007.05.001

  150. Izumi-Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, Koto T, Satofuka S, Inoue M, Tsubota K, Okano H, Oike Y, Ishida S. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170(6):2149-2158. doi:10.2353/ajpath.2007.061018

  151. Nagai N, Oike Y, Izumi-Nagai K, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Ishida S. Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: Minimal role of bradykinin. Invest Ophthalmol Vis Sci. 2007;48(5):2321-2326. doi:10.1167/iovs.06-1296

  152. Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H. SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007;303(2):591-600. doi:10.1016/j.ydbio.2006.11.032

  153. Satofuka S, Ichihara A, Nagai N, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Itoh H, Oike Y, Ishida S. Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization. Invest Ophthalmol Vis Sci. 2007;48(1):422-429. doi:10.1167/iovs.06-0534

  154. Kurihara T, Ozawa Y, Shinoda K, Nagai N, Inoue M, Oike Y, Tsubota K, Ishida S, Okano H. Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest Ophthalmol Vis Sci. 2006;47(12):5545-5552. doi:10.1167/iovs.06-0478

  155. Nagai N, Oike Y, Izumi-Nagai K, Urano T, Kubota Y, Noda K, Ozawa Y, Inoue M, Tsubota K, Suda T, Ishida S. Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2006;26(10):2252-2259. doi:10.1161/01.ATV.0000240050.15321.fe

  156. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Nakajima T, Shinoda H, Suzuki K, Kawaguchi N, Inoue M. Visual sensations during vitrectomy. Ophthalmology. 2006;113(10):1886-1887.

  157. Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006;47(6):2686-2692. doi:10.1167/iovs.05-1458

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