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Hisanori Imai, MD, PhD

Biography_Hisanori_Imai_MD_PhD

Expertises:

Surgical Retina, Complex Cataract Surgery

Current Affiliation:

Professor and Chair, Department of Ophthalmology, Kansai Medical University

Publications

  1. Mori S, Ueda K, Sakamoto M, Yamada-Nakanishi Y, Matsumiya W, Miki A, Imai H, Kusuhara S, Nakamura M. Differential diagnosis and clinical predictors in suspected optic neuritis. Jpn J Ophthalmol. 2025 Oct 23. doi:10.1007/s10384-025-01286-0.

  2. Oba S, Kiriishi T, Omi M, Hattori Y, Mori H, Ohnaka M, Hoshino T, Yamada H, Imai H. Short-Term Efficacy of Two-Step Treatment of Retinopathy of Prematurity in a Japanese Cohort: Anti-VEGF Therapy Followed by Routine Laser Photocoagulation. J Clin Med. 2025;14(19):7094. doi:10.3390/jcm14197094.

  3. Aya H, Araki-Sasaki K, Kobayashi Y, Fukuda K, Imai H. A Case of Orbital Inflammation as the Initial Manifestation of Eosinophilic Granulomatosis with Polyangiitis Following Dupilumab Administration, Successfully Treated with Mepolizumab. Ocul Immunol Inflamm. 2025;33(8):1894-1896. doi:10.1080/09273948.2025.2529342.

  4. Sotani Y, Imai H, Yamada H, Miki A, Nakamura M. Three-year outcomes of cystotomy for cystoid macular edema secondary to retinal vein occlusion. PLoS One. 2025;20(9):e0332941. doi:10.1371/journal.pone.0332941.

  5. Yamada H, Akiyama K, Sotani Y, Watanabe K, Matsuki T, Imai H, Noda T, Nakamura M. Outcomes of pneumatic retinopexy for primary rhegmatogenous retinal detachment in a Japanese cohort. Sci Rep. 2025;15(1):24182. doi:10.1038/s41598-025-09068-x.

  6. Imai H, Kishi M, Sotani Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Usefulness of a standardized scleral buckling technique for primary rhegmatogenous retinal detachment. PLoS One. 2025;20(5):e0323881. doi:10.1371/journal.pone.0323881.

  7. Yamada H, Imai H, Sotani Y, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Three-year outcomes of cystotomy and fibrinogen clot removal for diabetic macular edema with subfoveal cystoid macular edema. Sci Rep. 2025;15(1):16019. doi:10.1038/s41598-025-01197-7.

  8. Mori H, Kiriishi T, Omi M, Ohnaka M, Imai H. One-Year Outcomes of Trabeculotomy with 120°, 180°, or 360° Schlemm's Canal Incision for Primary Open-Angle Glaucoma: A Retrospective Study. J Clin Med. 2024;13(24):7653. doi:10.3390/jcm13247653.

  9. Yokota K, Yamada H, Mori H, Hattori Y, Omi M, Yamamoto Y, Toyama K, Imai H. Platelet-Derived Growth Factor Subunit A Strengthens the Neurovascular Unit and Inhibits Retinal Vascular Regression Under Hyperoxic Conditions. Int J Mol Sci. 2024;25(23):12945. doi:10.3390/ijms252312945.

  10. Hattori Y, Yamada H, Mori H, Oba S, Yokota K, Omi M, Yamamoto Y, Toyama K, Ohnaka M, Takahashi K, Imai H. The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis. Heliyon. 2024;10(21):e39843. doi:10.1016/j.heliyon.2024.e39843.

  11. Katakami K, Imai H, Sotani Y, Yamada H, Nakamura M. Factors regulating the gripping force and stiffness of 25- and 27-gauge internal limiting membrane forceps. PLoS One. 2024;19(11):e0310419. doi:10.1371/journal.pone.0310419.

  12. Sotani Y, Imai H, Kishi M, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. The Surgical Outcomes of Modified Intraocular Lens Suturing with Forceps-Assisted Haptics Extraction: A Clinical and Basic Evaluation. J Clin Med. 2024;13(18):5522. doi:10.3390/jcm13185522.

  13. Sotani Y, Imai H, Kishi M, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Removal of Subinternal Limiting Membrane Hemorrhage Secondary to Valsalva Retinopathy Using a Fovea-Sparing Internal Limiting Membrane Fissure Creation Technique. Case Rep Ophthalmol Med. 2024:2774155. doi:10.1155/2024/2774155.

  14. Imai H, Iwane Y, Kishi M, Sotani Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Color enhancement and achromatization to increase the visibility of indocyanine green-stained internal limiting membrane during digitally assisted vitreoretinal surgery. Jpn J Ophthalmol. 2024;68(2):105-111. doi:10.1007/s10384-023-01042-2.

  15. Sotani Y, Imai H, Iwane Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. High Intraocular Concentration of Fibrinogen Regulates Retinal Function Via the ICAM-1 Pathway. Invest Ophthalmol Vis Sci. 2024;65(13):34. doi:10.1167/iovs.65.13.34.

  16. Chubachi-Kamimura A, Miki A, Hayashida-Hirano M, Kishimoto-Kishi M, Okuda M, Matsumiya W, Imai H, Kusuhara S, Nakamura M. Aniseikonia after reduced-fluence photodynamic therapy in patients with central serous chorioretinopathy. Sci Rep. 2023;13(1):17133. doi:10.1038/s41598-023-44415-w.

  17. Kishi M, Miki A, Kamimura A, Okuda M, Matsumiya W, Imai H, Kusuhara S, Nakamura M. Short-Term Outcomes of Faricimab Treatment in Aflibercept-Refractory Eyes with Neovascular Age-Related Macular Degeneration. J Clin Med. 2023;12(15):5145. doi:10.3390/jcm12155145.

  18. Sotani Y, Imai H, Iwane Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Usefulness of intraoperative optical coherence tomography to minimize the intraocular lens tilt during the intrascleral fixation: a clinical and experimental evaluation. Sci Rep. 2023;13(1):12065. doi:10.1038/s41598-023-39294-0.

  19. Kimura A, Imai H, Iwane Y, Kishimoto M, Sotani Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. Removal of Sub-Internal Limiting Membrane Hemorrhage Secondary to Retinal Arterial Macroaneurysm Rupture: Internal Limiting Membrane Non-Peeling Technique. J Clin Med. 2023;12(9):3291. doi:10.3390/jcm12093291.

  20. Kamimura A, Miki A, Kishi M, Okuda M, Hayashida-Hirano M, Sakamoto M, Matsumiya W, Imai H, Kusuhara S, Nakamura M. Two-year outcome of half-time photodynamic therapy for chronic central serous chorioretinopathy with and without choroidal neovascularization. PLoS One. 2023;18(5):e0284979. doi:10.1371/journal.pone.0284979.

  21. Kusuhara S, Kishimoto-Kishi M, Matsumiya W, Miki A, Imai H, Nakamura M. Short-Term Outcomes of Intravitreal Faricimab Injection for Diabetic Macular Edema. Medicina (Kaunas). 2023;59(4):665. doi:10.3390/medicina59040665.

  22. Doi S, Kimura S, Saito S, Inoue M, Sakurai T, Kobori A, Hisatomi T, Imai H, Kuriyama S, Takasu I, Hosokawa MM, Shiode Y, Matoba R, Suzuki E, Morizane Y. IMPACT OF MACULAR INTRARETINAL HEMORRHAGE AND MACULAR HOLE ON THE VISUAL PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE. Retina. 2023;43(4):585-593. doi:10.1097/IAE.0000000000003725.

  23. Maki H, Imai H, Yamada H, Tetsumoto A, Hayashida M, Otsuka K, Miki A, Nakamura M. THE LONG-TERM EFFECT OF CYSTOTOMY WITH FIBRINOGEN CLOT REMOVAL FOR A CYSTOID MACULAR EDEMA SECONDARY TO IDIOPATHIC MACULAR TELANGIECTASIA TYPE 1: A CASE REPORT. Retin Cases Brief Rep. 2023;17(2):101-104. doi:10.1097/ICB.0000000000001117.

  24. Matsumiya W, Kusuhara S, Sotani N, Kim KW, Nishisho R, Sotani R, Imai H, Uji A, Nakamura M. Characteristics of Cellular Infiltration into Posterior Vitreous in Eyes with Uveitis on the Classification Basis Assessed Using Optical Coherence Tomography. Clin Ophthalmol. 2023;17:165-174. doi:10.2147/OPTH.S394441.

  25. Imai H, Tetsumoto A, Inoue S, Takano F, Yamada H, Hayashida M, Otsuka K, Miki A, Kusuhara S, Nakamura M. Intraoperative Three-Dimensional Fluorescein Angiography-Guided Pars Plana Vitrectomy for the Treatment of Proliferative Diabetic Retinopathy: The Maximized Utility of the Digital Assisted Vitrectomy. Retina. 2023;43(2):359-362. doi:10.1097/IAE.0000000000002805.

  26. Sotani Y, Imai H, Iwane Y, Yokogawa T, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M. INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY FOR REAL-TIME VISUALIZATION OF THE POSITIONAL RELATIONSHIP BETWEEN BUCKLING MATERIAL AND RETINAL BREAKS DURING SCLERAL BUCKLING FOR RHEGMATOGENOUS RETINAL DETACHMENT. Retina. 2022;42(12):2395-2400. doi:10.1097/IAE.0000000000003610.

  27. Iwane Y, Imai H, Yamada H, Sotani Y, Oishi M, Nakamura M. Removal of Subfoveal Massive Hard Exudates through an Intentional Macular Hole in Patients with Diabetic Maculopathy: A Report of Three Cases. Case Rep Ophthalmol. 2022;13(2):649-656. doi:10.1159/000526150.

  28. Nishida K, Morimoto T, Suzuki S, Iwahashi C, Imai H, Kuniyoshi K, Kusaka S. Pars plana vitrectomy for vitreoretinal complications in only seeing eyes after treatment for retinoblastoma. Am J Ophthalmol Case Rep. 2022;25:101367. doi:10.1016/j.ajoc.2022.101367.

  29. Imai H, Tetsumoto A, Yamada H, Hayashida M, Otsuka K, Miki A, Nakamura M. INTRAOPERATIVE THREE-DIMENSIONAL FLUORESCEIN ANGIOGRAPHY-GUIDED PARS PLANA VITRECTOMY FOR BRANCH RETINAL VEIN OCCLUSION. Retin Cases Brief Rep. 2022;16(6):802-805. doi:10.1097/ICB.0000000000001091.

  30. Kim KW, Kusuhara S, Imai H, Sotani N, Nishisho R, Matsumiya W, Nakamura M. Outcomes of Primary 27-Gauge Vitrectomy for 73 Consecutive Cases With Uveitis-Associated Vitreoretinal Disorders. Front Med (Lausanne). 2021;8:755816. doi:10.3389/fmed.2021.755816.

  31. Yamada H, Imai H, Tetsumoto A, Hayashida M, Otsuka K, Miki A, Nakamura M. The contribution of the proximity of the retinal detachment to the fovea for postoperative metamorphopsia after 27-gauge pars plana vitrectomy for the primary rhegmatogenous retinal detachment. PLoS One. 2021;16(10):e0258775. doi:10.1371/journal.pone.0258775.

  32. Sakai D, Imai H, Nakamura M. Multiple Intravitreal Liposomal Amphotericin B for a Case of Candida glabrata Endophthalmitis. Case Rep Ophthalmol. 2021;12(2):485-491. doi:10.1159/000511594.

  33. Sugimoto M, Kondo M, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Imai H, Nakamura M, Gabazza EC. Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema. Sci Rep. 2021;11(1):10449. doi:10.1038/s41598-021-89870-5.

  34. Maki H, Mori S, Imai H, Yamada H, Otsuka K, Miki A, Kusuhara S, Nakamura M. Autologous Scleral Pocket Technique for Ahmed Glaucoma Valve Implantation with Pars Plana Tube Insertion for Neovascular Glaucoma. J Clin Med. 2021;10(8):1606. doi:10.3390/jcm10081606.

  35. Zolov SN, Imai H, Losiewicz MK, Singh RSJ, Fort PE, Gardner TW. Insulin-like growth factor-2 regulates basal retinal insulin receptor activity. J Biol Chem. 2021;296:100712. doi:10.1016/j.jbc.2021.100712.

  36. Yamada H, Imai H, Tetsumoto A, Hayashida M, Otsuka K, Miki A, Kusuhara S, Nakamura M. Cystotomy with or without fibrinogen clot removal for refractory cystoid macular edema secondary to branch retinal vein occlusion. Sci Rep. 2021;11(1):8460. doi:10.1038/s41598-021-88149-z.

  37. Kim KW, Kusuhara S, Katsuyama-Yoshikawa A, Nobuyoshi S, Kitamura M, Mori S, Sotani N, Ueda K, Matsumiya W, Miki A, Kurimoto T, Imai H, Nakamura M. Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retinas. Antioxidants (Basel). 2021;10(3):455. doi:10.3390/antiox10030455.

  38. Chubachi A, Miki A, Hayashida M, Sakamoto M, Imai H, Kusuhara S, Nakamura M. Clinical Factors Associated with Low-Contrast Visual Acuity after Reduced-Fluence Photodynamic Therapy in Patients with Resolved Central Serous Chorioretinopathy and Good Baseline Visual Acuity. Pharmaceuticals (Basel). 2021;14(4):303. doi:10.3390/ph14040303.

  39. Miki A, Kusuhara S, Otsuji T, Kawashima Y, Miki K, Imai H, Nakamura M, Tsujikawa A. Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. PLoS One. 2021;16(3):e0248760. doi:10.1371/journal.pone.0248760.

  40. Imai H, Tetsumoto A, Yamada H, Nakamura M. Impact of different manufacturers and gauge sizes on the performance of backflush needle. Sci Rep. 2020;10(1):21452. doi:10.1038/s41598-020-78668-6.

  41. Hayashida M, Miki A, Nakai S, Matsumiya W, Imai H, Kusuhara S, Nakamura M. Predictive factors of metamorphopsia after reduced-fluence photodynamic therapy in patients with central serous chorioretinopathy with good baseline visual acuity. PLoS One. 2020;15(10):e0240557. doi:10.1371/journal.pone.0240557.

  42. Inoue S, Imai H, Tetsumoto A, Otsuka K, Nakamura M. A Rare Case of Lens-Induced Uveitis with Proliferative Vitreoretinopathy and Massive Encapsulation of Fallen Nuclear Material. Case Rep Ophthalmol. 2020;11(2):436-441. doi:10.1159/000508913.

  43. Hayashida M, Miki A, Nakai S, Matsumiya W, Imai H, Kusuhara S, Honda S, Nakamura M. Genetic factors associated with treatment response to reduced-fluence photodynamic therapy for chronic central serous chorioretinopathy. Mol Vis. 2020;26:505-509.

  44. Imai H, Tetsumoto A, Yamada H, Hayashida M, Otsuka K, Miki A, Kusuhara S, Nakamura M. LONG-TERM EFFECT OF CYSTOTOMY WITH OR WITHOUT THE FIBRINOGEN CLOT REMOVAL FOR REFRACTORY CYSTOID MACULAR EDEMA SECONDARY TO DIABETIC RETINOPATHY. Retina. 2021;41(4):844-851. doi:10.1097/IAE.0000000000002921.

  45. Matsumae H, Morizane Y, Yamane S, Yanagisawa S, Sakurai T, Kobori A, Imai H, Kanzaki Y, Suzuki E, Kadonosono K, Hayashi A, Shiraga F, Kuriyama S. Inverted Internal Limiting Membrane Flap versus Internal Limiting Membrane Peeling for Macular Hole Retinal Detachment in High Myopia. Ophthalmol Retina. 2020;4(9):919-926. doi:10.1016/j.oret.2020.03.021.

  46. Katsuyama A, Kusuhara S, Asahara SI, Nakai SI, Mori S, Matsumiya W, Miki A, Kurimoto T, Imai H, Kido Y, Ogawa W, Nakamura M. En face slab optical coherence tomography imaging successfully monitors progressive degenerative changes in the innermost layer of the diabetic retina. BMJ Open Diabetes Res Care. 2020;8(1):e001120. doi:10.1136/bmjdrc-2019-001120.

  47. Tetsumoto A, Imai H, Hayashida M, Otsuka K, Matsumiya W, Miki A, Nakamura M. The comparison of the surgical outcome of 27-gauge pars plana vitrectomy for primary rhegmatogenous retinal detachment between air and SF6 gas tamponade. Eye (Lond). 2020;34(2):299-306. doi:10.1038/s41433-019-0726-2.

  48. Hayashida M, Miki A, Imai H, Otsuka K, Azumi A, Nakamura M. Impact of Early Vitrectomy for Dense Vitreous Hemorrhage of Unknown Etiology. Ophthalmologica. 2019;242(4):234-238. doi:10.1159/000501723.

  49. Shinkai Y, Oshima Y, Yoneda K, Kogo J, Imai H, Watanabe A, Matsui Y, Suzuki K, Sotozono C, 27G Vitrectomy Study Group. Multicenter survey of sutureless 27-gauge vitrectomy for primary rhegmatogenous retinal detachment: a consecutive series of 410 cases. Graefes Arch Clin Exp Ophthalmol. 2019;257(12):2591-2600. doi:10.1007/s00417-019-04448-2.

  50. Tetsumoto A, Imai H, Otsuka K, Matsumiya W, Miki A, Nakamura M. Clinical factors contributing to postoperative aqueous flare intensity after 27-gauge pars plana vitrectomy for the primary rhegmatogenous retinal detachment. Jpn J Ophthalmol. 2019;63(4):317-321. doi:10.1007/s10384-019-00672-9.

  51. Imai H, Otsuka K, Tetsumoto A, Miki A, Nakamura M. EFFECTIVENESS OF EN BLOC REMOVAL OF FIBRINOGEN-RICH COMPONENT OF CYSTOID LESION FOR THE TREATMENT OF CYSTOID MACULAR EDEMA. Retina. 2020;40(1):154-159. doi:10.1097/IAE.0000000000002359.

  52. Otsuka K, Imai H, Fujii A, Miki A, Tagami M, Azumi A, Nakamura M. Comparison of 25- and 27-Gauge Pars Plana Vitrectomy in Repairing Primary Rhegmatogenous Retinal Detachment. J Ophthalmol. 2018:7643174. doi:10.1155/2018/7643174.

  53. Obata S, Miki A, Imai H, Nakamura M. Bilateral corneal denting after surgery under general anesthesia: A case report. Am J Ophthalmol Case Rep. 2018;10:290-292. doi:10.1016/j.ajoc.2018.04.011.

  54. Iwakawa Y, Imai H, Kaji H, Mori Y, Ono C, Otsuka K, Miki A, Oishi M. Autologous Transplantation of the Internal Limiting Membrane for Refractory Macular Hole following Ruptured Retinal Arterial Macroaneurysm: A Case Report. Case Rep Ophthalmol. 2018;9(1):113-119. doi:10.1159/000485914.

  55. Ubukata Y, Imai H, Otsuka K, Nishizaki M, Hara R, Uenishi M, Azumi A, Nakamura M. The Comparison of the Surgical Outcome for the Full-Thickness Macular Hole with/without Lamellar Hole-Associated Epiretinal Proliferation. J Ophthalmol. 2017:9640756. doi:10.1155/2017/9640756.

  56. Tetsumoto A, Imai H, Miki A, Nakamura M. A CASE OF RETINAL METASTASIS OF LARYNGEAL SQUAMOUS CELL CARCINOMA WITH HISTOPATHOLOGIC CONFIRMATION BY VITRECTOMY-ASSISTED EN BLOCK EXTRACTION. Retin Cases Brief Rep. 2020;14(2):127-130. doi:10.1097/ICB.0000000000000666.

  57. Otsuka K, Imai H, Miki A, Nakamura M. Impact of postoperative positioning on the outcome of pars plana vitrectomy with gas tamponade for primary rhegmatogenous retinal detachment: comparison between supine and prone positioning. Acta Ophthalmol. 2018;96(2):e189-e194. doi:10.1111/aos.13482.

  58. Bessho H, Imai H, Azumi A. The Histopathological Finding of the Surgically Extracted Atypical Dome-Shaped Choroidal Osteoma. Case Rep Ophthalmol Med. 2017:2874823. doi:10.1155/2017/2874823.

  59. Fukumoto T, Oka M, Masaki T, Sakaguchi M, Fukunaga A, Norose K, Sarayama Y, Imai H, Nishigori C. Cutaneous Rosai-Dorfman disease associated with uveitis. Eur J Dermatol. 2017;27(1):85-86. doi:10.1684/ejd.2016.2885.

  60. Honda S, Miki A, Kusuhara S, Imai H, Nakamura M. CHOROIDAL THICKNESS OF CENTRAL SEROUS CHORIORETINOPATHY SECONDARY TO CORTICOSTEROID USE. Retina. 2017;37(8):1562-1567. doi:10.1097/IAE.0000000000001380.

  61. Matsumiya W, Honda S, Otsuka K, Miki A, Nagai T, Imai H, Kusuhara S, Nakamura M. One-year outcome of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(3):541-548. doi:10.1007/s00417-016-3500-1.

  62. Imai H, Fujii A, Tani E, Azumi A. Wound Integrity of 2.0 mm Transconjunctival Single-Plane Sclerocorneal Incision: A Comparison between a Motorized Injector with/without Pause Time and a Manual Injector. J Ophthalmol. 2016:8129298. doi:10.1155/2016/8129298.

  63. Matsumiya W, Honda S, Otsuka K, Miki A, Nagai T, Imai H, Kusuhara S, Nakamura M. Comparison of the Effectiveness and Prognostic Factors of Intravitreal Ranibizumab between Typical Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy over 24 Months of Follow-Up. Ophthalmologica. 2015;234(1):33-39. doi:10.1159/000431000.

  64. Imai H, Misra GP, Wu L, Janagam DR, Gardner TW, Lowe TL. Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats. Invest Ophthalmol Vis Sci. 2015;56(13):7839-7846. doi:10.1167/iovs.15-16998.

  65. Imai H, Tagami M, Azumi A. Scleral buckling for primary rhegmatogenous retinal detachment using noncontact wide-angle viewing system with a cannula-based 25 G chandelier endoilluminator. Clin Ophthalmol. 2015;9:2103-2107. doi:10.2147/OPTH.S91339.

  66. Tagami M, Matsumiya W, Imai H, Kusuhara S, Honda S, Azumi A. Autologous antibodies to outer retina in acute zonal occult outer retinopathy. Jpn J Ophthalmol. 2014;58(6):462-472. doi:10.1007/s10384-014-0347-z.

  67. Fujii A, Imai H, Kanai M, Azumi A. Effect of intravitreal aflibercept injection for age-related macular degeneration with a retinal pigment epithelial tear refractory to intravitreal ranibizumab injection. Clin Ophthalmol. 2014;8:1199-1202. doi:10.2147/OPTH.S65810.

  68. Imai H, Azumi A. The Expansion of RPE Atrophy after the Inverted ILM Flap Technique for a Chronic Large Macular Hole. Case Rep Ophthalmol. 2014;5(1):83-86. doi:10.1159/000360693.

  69. Shimoyama T, Imai H, Honda S, Negi A. A case of choroidal neovascularization secondary to unilateral retinal pigment epithelium dysgenesis. Case Rep Ophthalmol. 2014;5(1):34-37. doi:10.1159/000358426.

  70. Otsuka K, Imai H, Shimoyama T, Nagai T, Honda S, Azumi A. Recurrence of macular hole retinal detachment after intravitreal ranibizumab injection for the treatment of choroidal neovascularization from the remaining macular hole edge. Case Rep Ophthalmol. 2012;3(3):424-427. doi:10.1159/000346041.

  71. Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA, Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M. Nanoliposomal minocycline for ocular drug delivery. Nanomedicine. 2013;9(1):130-140. doi:10.1016/j.nano.2012.03.004.

  72. Imai H, Honda S, Tsukahara Y, Negi A. Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. Case Rep Ophthalmol. 2011;2(3):314-318. doi:10.1159/000332830.

  73. Tagami M, Kusuhara S, Imai H, Honda S, Tsukahara Y, Negi A. Impact of intravitreal injection of tissue plasminogen activator on full-field electroretinogram in patients with macular oedema secondary to retinal vein occlusion. Ophthalmologica. 2011;226(2):81-86. doi:10.1159/000326242.

  74. Bessho H, Honda S, Imai H, Negi A. Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over 1 year of follow-up. Retina. 2011;31(8):1598-1602. doi:10.1097/IAE.0b013e31820d3f28.

  75. Matsumiya W, Honda S, Imai H, Kusuhara S, Tsukahara Y, Negi A. A Case of Bilateral Macular Holes Showing Onset and Spontaneous Closure over Very Short Intervals. Case Rep Ophthalmol. 2010;1(2):47-52. doi:10.1159/000320586.

  76. Tagami M, Kusuhara S, Imai H, Uemura A, Honda S, Tsukahara Y, Negi A. MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells. Biochem Biophys Res Commun. 2010;400(4):593-598. doi:10.1016/j.bbrc.2010.08.109.

  77. Fort PE, Rajala RV, Imai H, Gardner TW. Insulin signaling in normal and diabetic conditions. In: Signal Transduction: Pathways, Mechanisms and Diseases. New York, NY: Springer; 2009

  78. Imai H, Singh RS, Fort PE, Gardner TW. Neuroprotection for Diabetic Retinopathy. In: Developments in Oophthalmology. Basel, Switzerland: Karger; 2009:56-68.

  79. Imai H, Singh RSJ, Fort PE, Gardner TW. Neuroprotection for diabetic retinopathy. Dev Ophthalmol. 2009;44:56-68. doi:10.1159/000223946.

  80. Imago M, Imai H, Nakanishi Y, Azumi A. Optical coherence tomography for monitoring the process of Candida endophthalmitis. Acta Ophthalmol. 2009;87(6):680-682. doi:10.1111/j.1755-3768.2008.01297.x.

  81. Honda S, Imai H, Yamashiro K, Kurimoto Y, Kanamori-Matsui N, Kagotani Y, Tamura Y, Yamamoto H, Ohoto S, Takagi H, Uenishi M, Negi A. Comparative assessment of photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a multicenter study in Hyogo prefecture, Japan. Ophthalmologica. 2009;223(5):333-338. doi:10.1159/000221837.

  82. Imai H, Azumi A, Nagai T, Yamamoto H, Negi A, Ohbayashi C. A case of ocular toxoplasmosis: direct proof of the protozoan infection by retinal biopsy. Retin Cases Brief Rep. 2008;2(1):76-79. doi:10.1097/01.iae.0000249391.22195.bd.

  83. Nagai T, Imai H, Honda S, Negi A. Antiangiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(12):5716-5721. doi:10.1167/iovs.07-1023.

  84. Imai H, Honda S, Kondo N, Ishibashi K, Tsukahara Y, Negi A. The upregulation of angiogenic gene expression in cultured retinal pigment epithelial cells grown on type I collagen. Curr Eye Res. 2007;32(10):903-910. doi:10.1080/02713680701604749.

  85. Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, Hirata A, Kawaji T, Fukushima M, Tanihara H, Negi A. Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: a preliminary trial. Am J Ophthalmol. 2007;144(1):139-141. doi:10.1016/j.ajo.2007.03.020.

  86. Imai H, Honda S, Nakanishi Y, Yamamoto H, Tsukahara Y, Negi A. Different transitions of multifocal electroretinogram recordings between patients with age-related macular degeneration and polypoidal choroidal vasculopathy after photodynamic therapy. Br J Ophthalmol. 2006;90(12):1524-30.

  87. Imai H, Kusuhara S, Nakanishi Y, Teraoka Escaño MF, Yamamoto H, Tsukahara Y, Negi A. A case of POEMS syndrome with cystoid macular edema. Am J Ophthalmol. 2005;139(3):563-566. doi:10.1016/j.ajo.2004.09.016.

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