1. Mandai M, Takanashi T, Ogura Y, Honda Y. Proliferative vitreoretinopathy shows predilection for the inferior fundus. Graefes Arch Clin Exp Ophthalmol, 1990, 228:335-7
2. Mandai M, Iwaki M, Honda Y. Simple and accurate assay for tyrosine hydroxylase from bovine retina by high-performance liquid chromatography with fluorescence detection. Ophthalmic Res, 1992, 24:228-33
3. Mandai M, Iwaki M, Honda Y. Catalytic nature of tyrosine hydroxylase in bovine ocular tissues. J Biochem (Tokyo), 1994, 115:797-802
4. Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest Ophthalmol Vis Sci, 1994, 35:3673-80
5. Mandai M, Mittag TW, Kogishi J, Iwaki M, Hangai M, Yoshimura N. Role of nitric oxide synthase isozymes in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci, 1996, 37:826-32
6. Suzuma K, Mandai M, Kogishi J, Tojo SJ, Honda Y, Yoshimura N. Role of P-selectin in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci, 1997, 38:1610-1618
7. Suzuma I, Mandai M, Suzuma K, Ishida K, Tojo SJ, Honda Y. Contribution of E-selectin to cellular infiltration during endotoxin-induced uveitis. Invest Ophthalmol Vis Sci, 1998, 39(9):1620-30
8. Miyamoto N, Mandai M, Suzuma I, Suzuma K, Kobayashi K, Honda Y. Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis. J Immunol, 1999, 163:374-9
9. Suzuma I, Mandai M, Takagi H, Suzuma K, Otani A, Oh H, Kobayashi K, Honda Y. 17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci, 1999, 40:2122-2129
10. Mandai M, Takahashi M, Miyamoto H, Hiroshiba N, Kimura H, Ogura Y, Honda Y, Sasai K. Long-term outcome after radiation therapy for subfoveal choroidal neovascularization associated with age-related macular degeneration. Jpn J Ophthalmol, 2000, 44:530-7
11. Miyamoto N, Mandai M, Takagi H, Suzuma I, Suzuma K, Koyama S, Otani A, Oh H, Honda Y. Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP. Invest Ophthalmol Vis Sci, 2002, 43(6):2007-14
12. Takesono A, Horai R, Mandai M, Dombroski D, Schwartzberg PL. Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol, 2004, 14(10):917-22
13. Tanemura M, Miyamoto N, Mandai M, Kamizuru H, Ooto S, Yasukawa T, Takahashi M, Honda Y. The role of estrogen and estrogen receptorbeta in choroidal neovascularization. Mol Vis, 2004, 10:923-32
14. Suzuki T, Mandai M, Akimoto M, Yoshimura N, Takahashi M. The simultaneous treatment of MMP-2 stimulants in retinal transplantation enhances grafted cell migration into the host retina. Stem Cells, 2006, 24(11):2406-11
15. Oishi A, Nagai T, Mandai M, Takahashi M, Yoshimura N. The effect of dendritic cells on the retinal cell transplantation. Biochem Biophys Res Commun, 2007, 363(2):292-6
16. Jin ZB, Mandai M, Yokota T, Higuchi K, Ohmori K, Ohtsuki F, Takakura S, Itabashi T, Wada Y, Akimoto M, Ooto S, Suzuki T, Hirami Y, Ikeda H, Kawagoe N, Oishi A, Ichiyama S, Takahashi M, Yoshimura N, Kosugi S. Identifying pathogenic genetic background of simplex or multiplex retinitispigmentosa patients: a large scale mutation screening study. J Med Genet, 2008, 45:465-72
17. Mandai M, Ikeda H, Jin ZB, Iseki K, Ishigami C, Takahashi M. Use of lectins to enrich mouse ES-derived retinal progenitor cells for the purpose of transplantation therapy. Cell Transplant, 2010, 19(1):9-19
18. Oishi A, Mandai M, Kimakura M, Nishida A, Kurimoto Y. Characteristics of fine vascular network pattern associated with recurrence of polypoidal choroidal vasculopathy. Eye, 2011, 25:1020-6
19. Oishi A, Kojima H, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Fujihara M, Bessho N, Uenishi M, Kurimoto Y, Negi A. Comparison of the effect of ranibizumab and verteporfin for polypoidal choroidal vasculopathy: 12-month LAPTOP study results. Am J Ophthalmol, 2013, 156(4):644-51
20. Oishi A, Miyamoto N, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Bessho N, Uenishi M, Kurimoto Y, Negi A. LAPTOP study: a 24-month trial of verteporfin versus ranibizumab for polypoidal choroidal vasculopathy. Ophthalmology, 2014, 121(5):1151-2
21. Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, Kiryu J, Takahashi M. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Reports, 2014, 2(2):205-18
22. Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports, 2014, 2(5):662-74
23. Sun J, Mandai M, Kamao H, Hashiguchi T, Shikamura M, Kawamata S, Sugita S, Takahashi M. Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice. Stem Cells, 2015, 33(5):1543-53
24. Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A, 2016, 113(1):E81-90
25. Mandai M, Homma K, Okamoto S, Yamada C, Nomori A, Takahashi M. Adequate Time Window and Environmental Factors Supporting Retinal Graft Cell Survival in rd Mice. Cell Med, 2012, 4(1):45-54
26. Fujii M, Sunagawa GA, Kondo M, Takahashi M, Mandai M. Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function. Sci Rep, 2016, 6:30719
27. Iraha S, Hirami Y, Ota S, Sunagawa GA, Mandai M, Tanihara H, Takahashi M, Kurimoto Y. Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study. Clin Ophthalmol, 2016, 10:1375-84
28. Mandai M, Fujii M, Hashiguchi T, Sunagawa GA, Ito SI, Sun J, Kaneko J, Sho J, Yamada C, Takahashi M. iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice. Stem Cell Reports, 2017, 8(1):69-83
29. Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H, Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata KI, Sawada M, Yamamoto M, Ohta S, Ohara Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa S, Yamanaka S, Takahashi M. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med, 2017, 376(11):1038-1046
30. Miyamoto N, Mandai M, Kojima H, Kameda T, Shimozono M, Nishida A, Kurimoto Y. Response of eyes with age-related macular degeneration to anti-VEGF drugs and implications for therapy planning. Clin Ophthalmol, 2017, 11:809-816
31. Takagi S, Mandai M, Miyamoto N, Nishida A, Hirami Y, Uyama H, Yamamoto M, Takahashi M, Tomita G, Kurimoto Y. Incidence of outer retinal tubulation in eyes with choroidal neovascularization under intravitreal anti-vascular endothelial growth factor therapy in a Japanese population. Clin Ophthalmol, 2017, 11:1219-1225
32. Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M. Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation. Stem Cell Reports, 2018, 10(3):1059-1074
33. Miyamoto N, Mandai M, Oishi A, Nakai S, Honda S, Hirashima T, Oh H, Matsumoto Y, Uenishi M, Kurimoto Y. Long-term results of photodynamic therapy or ranibizumab for polypoidal choroidal vasculopathy in LAPTOP study. Br J Ophthalmol, 2019, 103(6):844-848
34. Tu HY, Watanabe T, Shirai H, Yamasaki S, Kinoshita M, Matsushita K, Hashiguchi T, Onoe H, Matsuyama T, Kuwahara A, Kishino A, Kimura T, Eiraku M, Suzuma K, Kitaoka T, Takahashi M, Mandai M. Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration. EBioMedicine, 2019, 39:562-574
35. Akiba R, Matsuyama T, Tu HY, Hashiguchi T, Sho J, Yamamoto S, Takahashi M, Mandai M. Quantitative and Qualitative Evaluation of Photoreceptor Synapses in Developing, Degenerating and Regenerating Retinas. Front Cell Neurosci, 2019; 13: 16. Published online 2019 Feb 11. doi: 10.3389/fncel.2019.00016
36. Takagi S, Mandai M, Gocho K, Hirami Y, Yamamoto M, Fujihara M, Sugita S, Kurimoto Y, Takahashi M. Evaluation of Transplanted Autologous Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in Exudative Age-Related Macular Degeneration. Ophthalmol Retina, 2019, 3(10):850-859
37. Matsuzaki M, Mandai M, Yamanari M, Totani K, Nishida M, Sugita S, Maeda T, Koide N, Takagi S, Hirami Y, Miyamoto N, Sugiyama S, Takahashi M, Kurimoto Y. Polarization-sensitive optical coherence tomography for estimating relative melanin content of autologous induced stem-cell derived retinal pigment epithelium. Sci Rep, 2020, 10(1):7656
38. Sugita S, Mandai M, Hirami Y, Takagi S, Maeda T, Fujihara M, Matsuzaki M, Yamamoto M, Iseki K, Hayashi N, Hono A, Fujino S, Koide N, Sakai N, Shibata Y, Terada M, Nishida M, Dohi H, Nomura M, Amano N, Sakaguchi H, Hara C, Maruyama K, Daimon T, Igeta M, Oda T, Shirono U, Tozaki M, Totani K, Sugiyama S, Nishida K, Kurimoto Y, Takahashi M. HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration. J Clin Med, 2020, 9(7):2217
39. Yamasaki S, Sugita S, Horiuchi M, Masuda T, Fujii S, Makabe K, Kawasaki A, Hayashi T, Kuwahara A, Kishino A, Kimura T, Takahashi M, Mandai M. Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas. Stem Cell Reports, 2021, 16(4):851-867
40. Matsuyama T, Tu HY, Sun J, Hashiguchi T, Akiba R, Sho J, Fujii M, Onishi A, Takahashi M, Mandai M. Genetically engineered stem cell-derived retinal grafts for improved retinal reconstruction after transplantation. iScience, 2021, 24(8):102866
41. Nishida M, Tanaka Y, Tanaka Y, Amaya S, Tanaka N, Uyama H, Masuda T, Onishi A, Sho J, Yokota S, Takahashi M, Mandai M. Human iPS cell derived RPE strips for secure delivery of graft cells at a target place with minimal surgical invasion. Sci Rep. 2021 Nov 2;11(1):21421. doi: 10.1038/s41598-021-00703-x.
42. Wu YR, Hashiguchi T, Sho J, Chiou SH, Takahashi M, Mandai M. Transplanted Mouse Embryonic Stem Cell-Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):26. doi: 10.1167/iovs.62.13.26.
43. Yamasaki S, Tu HY, Matsuyama T, Horiuchi M, Hashiguchi T, Sho J, Kuwahara A, Kishino A, Kimura T, Takahashi M, Mandai M. A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation. iScience. 2021 Dec 20;25(1):103657. doi: 10.1016/j.isci.2021.103657. eCollection 2022 Jan 21.
44. Motozawa N, Miura T, Ochiai K, Yamamoto M, Horinouchi T, Tsuzuki T, Kanda GN, Ozawa Y, Tsujikawa A, Takahashi K, Takahashi M, Kurimoto Y, Maeda T, Mandai M. Automated evaluation of retinal pigment epithelium disease area in eyes with age-related macular degeneration. Sci Rep. 2022 Jan 18;12(1):892. doi: 10.1038/s41598-022-05006-3.
45. Uyama H, Tu HY, Sugita S, Yamasaki S, Kurimoto Y, Matsuyama T, Shiina T, Watanabe T, Takahashi M, Mandai M.: Competency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates. Stem Cell Reports. 2022 Nov 8;17(11):2392-2408. doi: 10.1016/j.stemcr.2022.09.014. Epub 2022 Oct 27.
46. Watari K, Yamasaki S, Tu HY, Shikamura M, Kamei T, Adachi H, Tochitani T, Kita Y, Nakamura A, Ueyama K, Ono K, Morinaga C, Matsuyama T, Sho J, Nakamura M, Fujiwara M, Hori Y, Tanabe A, Hirai R, Terai O, Ohno O, Ohara H, Hayama T, Ikeda A, Nukaya D, Matsushita K, Takahashi M, Kishino A, Kimura T, Kawamata S, Mandai M, Kuwahara A. Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy. Commun Biol. 2023 Feb 10;6(1):164. doi: 10.1038/s42003-023-04543-5.
47. Yamamoto M, Matsuyama T, Maeda T, Takagi S, Motozawa N, Sakai D, Hirami Y, Maeda A, Kurimoto, Y, Takahashi M, Mandai M. Detailed Evaluation of Chromatic Pupillometry and Full-Field Stimulus Testing to Assess Ultralow Vision in Retinitis Pigmentosa. Ophthalmol Sci. 2023 May 8;3(4):100328. doi: 10.1016/j.xops.2023.100328. eCollection 2023 Dec.
48. Hirami Y, Mandai M, Sugita S, Maeda A, Maeda T, Yamamoto M, Uyama H, Yokota S, Fujihara M, Igeta M, Daimon T, Fujita K, Tomoko Ito T, Shibatani N, Morinaga C, Hayama T, Nakamura A, Ueyama K, Ono K, Ohara H, Fujiwara M, Yamasaki S, Watari K, Bando K, Kawabe K, Ikeda A, Kimura T, Kuwahara A, Takahashi M, Kurimoto Y. Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa. Cell Stem Cell. 2023 Dec 7;30(12):1585-1596.e6. doi: 10.1016/j.stem.2023.11.004.
49. Iwama Y, Nomaru H, Masuda T, Kawamura Y, Matsumura M, Murata Y, Teranishi K, Nishida K, Ota S, Mandai M, Takahashi M. Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies. Stem Cell Reports. 2023 Dec 20:S2213-6711(23)00463-0. doi: 10.1016/j.stemcr.2023.12.001. Online ahead of print.
50. Sakai D, Maeda T, Yamamoto M, Yokota S, Maeda A, Hirami Y, Nakamura M, Kurimoto Y, Mandai M. Relationship between residual visual field and full-field stimulus testing in patients with late-stage retinal degenerative diseases. Sci Rep. 2024 Feb 2;14(1):2793. doi: 10.1038/s41598-024-53474-6.
51. Kitahata S, Mandai M, Ichikawa H, Tanaka Y, Senba T, Kajita K, Sugita S, Kadonosono K, Takahashi M. Investigation of the effectiveness of gelatin hydrolysate in human iPS-RPE cell suspension transplantation. Regen Ther. 2024 Jan 11;25:238-249. doi: 10.1016/j.reth.2023.12.016. eCollection 2024 Mar.
52. Kajita K, Nishida M, Kurimoto Y, Yokota S, Sugita S, Semba T, Shirae S, Hayashi N, Ozaki A, Miura Y, Maeda A, Mitamura Y, Takahashi M, Mandai M. Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage. Sci Rep. 2024 May 2;14(1):10044. doi: 10.1038/s41598-024-60895-w.
53. Ishikura M, Muraoka Y, Hirami Y, Tu HY, Mandai M. Adaptive Optics Optical Coherence Tomography Analysis of Induced Pluripotent Stem Cell-Derived Retinal Organoid Transplantation in Retinitis Pigmentosa. Cureus. 2024 Jul 19;16(7):e64962. doi: 10.7759/cureus.64962. eCollection 2024 Jul.
54. Akiba R, Lind Boniec S, Knecht S, Uyama H, Tu HY, Baba T, Takahashi M, Mandai M, Wong RO. Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2413104121. doi: 10.1073/pnas.2413104121. Epub 2024 Sep 4.
55. Iwama Y, Sugase-Miyamoto Y, Onoue K, Uyama H, Matsuda K, Hayashi K, Akiba R, Masuda T, Yokota S, Yonemura S, Nishida K, Takahashi M, Kurimoto Y, Mandai M. Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole. Stem Cell Reports. 2024 Feb 13;19(2):254-269. doi: 10.1016/j.stemcr.2023.12.001. Epub 2024 Jan 4.
56. Akiba R, Tu HY, Hashiguchi T, Takahashi Y, Toyooka K, Tsukamoto Y, Baba T, Takahashi M, Mandai M. Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation. Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):8. doi: 10.1167/iovs.65.12.8.
57. Hirami Y, Mandai M. Opening the door to widespread iPSC-derived regenerative therapy for corneal epithelial opacity. Lancet. 2024 Nov 16;404(10466):1898-1899. doi: 10.1016/S0140-6736(24)01965-2. Epub 2024 Nov 7. PMID: 39522525.
58. Watanabe M, Yamada T, Koike C, Takahashi M, Tachibana M, Mandai M. Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas. Stem Cell Reports. 2025 Jan 3:102393. doi: 10.1016/j.stemcr.2024.102393. Epub ahead of print. PMID: 39824188.
59. Sakai D, Mandai M, Hirami Y, Yamamoto M, Ito SI, Igarashi S, Yokota S, Uyama H, Fujihara M, Maeda A, Terada M, Nishida M, Shibata Y, Hayashi N, Iseki K, Miura T, Kajita K, Ishida M, Sugita S, Maeda T, Takahashi M, Kurimoto Y. Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Strips for Macular Degeneration and Retinitis Pigmentosa. Ophthalmol Sci. 2025 Mar 18;5(4):100770. doi: 10.1016/j.xops.2025.100770. eCollection 2025 Jul-Aug.
60. Ozaki A, Sugita S, Ishida M, Nishida M, Iseki K, Sakai N, Hayashi N, Shiina T, Yokota S, Ito SI, Fujihara M, Kondo M, Takahashi M, Kurimoto Y, Mandai M. Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes. Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):53. doi: 10.1167/iovs.66.6.53.
61. Watanabe M, Yamada T, Tu HY, Chaya T, Okayama S, Onoue K, Yonemura S, Koike C, Tachibana M, Furukawa T, Mandai M. Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation. Stem Cell Reports. 2025 Jul 8;20(7):102545. doi: 10.1016/j.stemcr.2025.102545. Epub 2025 Jun 26.
62. Igarashi S, Mandai M, Totani K, Yamanari M, Sakai D, Yamamoto M, Hirami Y, Sugiyama S, Kurimoto Y. Characterization of the depolarization contrast line in the outer retina using polarization-sensitive optical coherence tomography. Sci Rep. 2025 Jul 14;15(1):25394. doi: 10.1038/s41598-025-11111-w.
63. Iwama Y, Masuda T, Yoshimura M, Watanabe M, Ohigashi Y, Friedlander M, Nishida K, Takahashi M, Nikaido I, Mandai M. Genomic characterization of sub- populations in human pluripotent stem cell-derived retinal progenitor cells driving retinal lamination. Stem Cell Reports. 2026 Apr 14;21(4):102831. doi: 10.1016/j.stemcr.2026.102831. Epub 2026 Mar 5. PMID: 41791386; PMCID: PMC13083797.
64. Ozaki A, Kawai A, Akiba R, Okayama S, Ohno N, Kajita K, Masuda T, Yokota S, Ito SI, Peiyan D, Onoue K, Yonemura S, Kondo M, Kurimoto Y, Fu Y, Mandai M. Long-term functional synaptic integration of genome-edited retinal organoids in a primate model of macular degeneration. Mol Ther. 2026 Jun 27:S1525-0016(26)00515-0. doi: 10.1016/j.ymthe.2026.06.037. Epub ahead of print. PMID: 42365435.