BIBLOGRAPHY (selected from 132 manuscripts)
Clinical studies:
1. Hirami Y, Mandai M, Sugita S, Maeda A, Maeda T, Yamamoto M, Uyama H, Yokota S, Fujihara M, Igeta M, Daimon T, Fujita K, Ito T, Shibatani Nm Morinaga C, Hayama T, Nakamura A, Ueyama K, Ono K, Ohara H, Fujiwata M, Yamasaki S, Watari K, Bando K, Kawabe K, Ikeda A, Kuwahara A, Takahashi M, Kurimoto Y. Cell Stem Cell, 2023; 30, 1585-1596. PMID38065067
2. Kitahata S, Gocho K, Motozawa N, Yokota S, Yamamoto M, Maeda A, Hirami Y, Kurimoto Y, Kadonosono K, Takahashi M. Evaluation of photoreceptor features in retinitis pigmentosa with cystoid macular edema by using an adaptive optics fundus camera. PLoS One, 2024; 19, e0296493. PMID38166083
3. Mizobuchi K, Hayashi T, Tanaka K, Kuniyoshi K, Murakami Y, Nakamura N, Torii K, Mizota A, Sakai D, Maeda A, Kominami T, Ueno S, Kusaka S, Nishiguchi KM, Ikeda Y, Kondo M, Tsunoda K, Hotta Y, Nakano T. Genetic and clinical features of ABCA4-associated retinopathy in a Japanese nationwide cohort. Am J Ophthalmol., 2024; 264, 36-43. PMID38499139
4 Sakai D, Maeda T, Yamamoto M, Yokota S, Maeda A, Hirami Y, Nakamura M, Kurimoto Y, Mandai M. Relationship between residual visual field and full-field stimulus testing in patients with late-stage retinal degenerative diseases. Sci Rep., 2024; 14, 2793. PMID38307956
5. Sakai D, Hiraoka M, Matsuzaki M, Yokota S, Hirami Y, Onishi A, Nakamura M, Takahashi M, Kurimoto Y, Maeda A. Genotype and phenotype characteristics of RHO-associated retinitis pigmentosa in the Japanese population. Jpn J Opththalmol. 2023; 67, 138-148. PMID36648560
6. Yamamoto M, Matsuyama T, Maeda T, Takagi S, Motozawa N, Sakai D, Maeda A, Kurimoto Y, Takahashi M, Mandai M. Detaied evaluation of chromatic pupillometry and full-field stimulus testing to assess ultralow vision in retinitis pigmentosa. Ophthalmic Sci., 2023; 3, 100328. PMID37920419
7. Sakai D, Takagi S, Totani K, Yamamoto M, Matsuzaki M, Yamanari M, Sugiyama S, Yokota S, Maeda A, Hirami Y, Mandai M, Takahashi M, Nakamura M, Kurimoto Y. Retinal pigment epithelium melanin imaging using polarization-sensitive optical coherence tomography for patients with retinitis pigmentosa. Sci Rep., 2022; 12, 7155. PMID35504937.
8. Maeda A, Yoshida A, Kawai K, Arai Y, Akiba R, Inaba A, Takagi S, Fujiki R, Hirami Y, Kurimoto Y, Ohara O,
Takahashi M. Development of a molecular diagnostic test for retinitis pigmentosa in the Japanese population.
Jpn. J. Ophthalmol., 2018;62, 451-457. PMID29785639

Therapeutic development; Gene therapy
1. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya Am Sun W, Maeda A, Kern T, Palcewski, K, Lu ZR. Non-viral
Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles., Mol Therapy, 2019; 19, 30413-30417. PMID31611143
2. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted multifunctional lipid
ECO plasmid DNA nanoparticles as efficient non-viral gene therapy for Leber’s Congenital Amaurosis. Mol Ther Nucleic Acids. 2017; 7, 42-52. PMID:28624218
3. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski T, Lu ZR Self-assembly of a multifunctional lipid with core-shell dendrimer DNA nanoparticles enhanced efficient gene delivery at low charge ratios into RPE cells. Macromole Biosci. 2015; 10-201500192 PMC4770799

Therapeutic development; Cell therapy
1. Kajita K, Nishida M, Kurimoto Y, Yokota S, Sugita S, Semba T, Shirae S, Hayashi N, Ozaki A, Miura Y, Maeda A, Mitamura Y, Takahashi M, Mandai M. Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage. Sci Rep., 2024; 14, 10044. PMID38698112
2. Nakai-Futatsugi Y, Jin J, Ogawa T, Sakai N, Maeda A, Hironaka KI, Fukuda M, Danno H, Tanaka Y, Hori S, Shiroguchi K, Takahashi M. Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile. Elife; 2024; 12, RP92510. PMID38722314
3. Woogeng IN, Kaczkowski B, Abugessaisa I, Hu H, Tachibana A, Sahara Y, Hon CC, Hasegawa A, Sakai N, Nishida M, Sanyal H, Sho J, Kajita K, Kasukawa T, Takasato M, Carninci P, Maeda A, Mandai M, Arner E, Takahashi M, Kime C. Inducing human retinal pigment epithelium-like cells from somatic tissue. Stem Cell Reports. 2022; 17, 289-306. PMID35030321
4. Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar P, Palczewski K, Takahashi M, Maeda A. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J. Biol. Chem. 2013; 288, 34484-34493. PMC3843063

Therapeutic development; Pharmacological therapy
1. Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat. Chem. Biol. 2011; 8, 170-178. PMC3518042
2. Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multi-photon fluorescence microscopy resolves retinol and retinal-condensation products in mouse eyes. Nat Med. 2010; 16, 1444-1449. PMC3057900
3. Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. Multifunctional PEG retinylamine
conjugate prolonged protection against retinal degeneration in mice. Biomacromolecules 2014, 15, 4570-4578. PMC4261990
4. Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials 2015, 44, 103-110. PMC4393824
5. Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu Z-R. Syntheisis and evaluation of a nanoglobular dendrimer 5-aminosalycylic acid conjugate with an acid-senseitive Schiff base spacer for treating retinal degeneration. ACS Nano, 2014; 8, 153-61. PMC4060971
6. Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology approach to prevent retinal degeneration in Stargardt disease. J Clin Invest, 2013; 123, 5119-534. PMC3889412
7. Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for Stargardt disease and age-related macular degeneration. J. Biol. Chem. 2012; 287, 5059-69. PMC3281612

Retinal Biochemistry
1. Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+ - binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat. Neurosci. 2004; 7, 1079-1087. PMC1352161
2. Maeda A, Palczewska, G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy
reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc. Natl. Acad. Sci. USA. 2014; 111, 1428-37. PMC3986171
3. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc. Natl. Acad. Sci. USA. 2010; 107, 8428-8433. PMC2889565
4. Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc. Natl. Acad. Sci. USA. 2007; 104, 19565-19570. PMC2148329
5. Parmar VM, Parmar T, Arai E, Perusek L, Maeda A. A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells. Stem Cell Res., 2018;27, 95-104. PMID29358124
6. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect from light-induced retinal degeneration in mouse models. FASEB J., 2018;117, 111294. PMID28645515.29401616
7. Parmar T, Parmar VM, Perusek L, Georges A, Takahashi M, Maeda A. Lipocalin 2 plays an important role in regulating inflammation in retinal degeneration. J Immunol., 2018;200, 3128-3141. PMID29602770
8. Arai E, Parmar VM, Sahu B, Perusek L, Parmar T, Maeda A. Docosahexaenoic acid promotes differentiation of photoreceptor cell in three-dimensional neural retinas. Neurosci. Res. 2017; S0168-0102, 30318-2. PMID28433627
9. Parmar P, Parmar VM, Arai E, Sahu B, Perusek L, Maeda A. Acute stress responses are early molecular
events of retinal degeneration in Abca4-/-Rdh8-/- mice after light exposure. Invest. Ophthal¬mol. Vis. Sci. 2016;57, 3257-3267. PMID27315541
10. Palczewska G, Maeda A*, #, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor tyrosine kinase MERTK is not required for transfer of bis-retinoids to the retinal pigmented epithelium. J. Biol. Chem. 2016; 291, 26937-49. PMID27875314 (*Co-First author, #Co-corresponding author)
11. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional ablation of
retinol dehydrogenase 10 in the retinal pigmented epithelium causes delayed dark adaptation in mice. J. Biol. Chem. 2015; 290, 27239-47. PMID26391396
12. Perusek L. Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. A2E
accumulation and the maintenance of the visual cycle are independent of Atg7-mediated autophagy in the retinal pigmented epithelium. J. Biol. Chem. 2015; 290, 29035-44. PMID26468292
13. Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A. CCL3 production from microglial cells modulates severity of retinal degeneration in mouse models. J. Immunol. 2014; 192, 3816-27. PMID24639355
14. Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A. Autophagy protects the retina from light-induced degeneration. J. Biol. Chem. 2013; 288, 7506-18. PMID23341467
15. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J. Biol. Chem. 2013; 288, 15326-41. PMID23572532
16. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-
like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J. Biol. Chem. 2011; 286, 15543-55. PMID21383019