1. Ozawa Y, Onozato N, Togawa H, Shimmura S. Associations between retinal thickness and background factors in eyes without retinal diseases. Sci Rep. 2025;15(1):21796. doi:10.1038/s41598-025-06863-4
2. Mushiga Y, Nagai N, Ozawa Y. Associations between serum lipid levels and the macular retinal volumes in patients with diabetes. PLoS One. 2025;20(6):e0325500. doi:10.1371/journal.pone.0325500
3. Sugisawa T, Gomi F, Harada Y, Imaizumi H, Aoki S, Miki A, Kishi M, Yamauchi T, Nagasato D, Ozawa Y, Haruta M, Kato N, Matsubara H, Yasukawa T, Kato A, Terasaki H, Hirano T, Iesato Y, Tsujinaka H, Murakami T, Mitamura Y, Wakuta M, Kimura K, Shimura M. Factors that contribute to loss to follow-up in the medium term after initiation of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in Japanese patients. PLoS One. 2025;20(6):e0325963. doi:10.1371/journal.pone.0325963
4. Nagai N, Matsubara H, Terasaki H, Hirano T, Kato A, Miki A, Hirai H, Murao F, Imaizumi H, Gomi F, Mitamura Y, Ogata N, Kusuhara S, Yasukawa T, Murata T, Sakamoto T, Kondo M, Shinoda H, Ozawa Y. Extent of Complete Retinal Pigment Epithelial and Outer Retinal Atrophy with Foveal Center Involvement is Associated with Visual Acuity. Ophthalmol Sci. 2025;5(1):100612. doi:10.1016/j.xops.2024.100612
5. Ozawa Y, Yoshihara K, Mezghani M, Pierzchala P, Nikodem M, Barbier S, Nomoto M, Aitoku Y. Recent daily life burdens associated with neovascular age-related macular degeneration involve difficulties in use of electronic devices. Sci Rep. 2024;14(1):14181. doi:10.1038/s41598-024-65089-y
6. Sonoda K, Komatsu M, Ozawa Y, Yamamoto H, Kamijo Y. Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study. Biomedicines. 2024;12(4):849. doi:10.3390/biomedicines12040849
7. Nagai N, Mushiga Y, Ozawa Y. Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels. Sci Rep. 2023;13(1):22570. doi:10.1038/s41598-023-50132-1
8. Tezuka T, Shibata M, Hanaoka H, Izawa Y, Kikuchi T, Akino K, Ozawa Y, Saito M, Kaneko Y, Nakahara J, Takizawa T. Systemic lupus erythematosus mimicking retinal migraine: a case report. Cephalalgia. 2023;43(12):03331024231219477. doi:10.1177/03331024231219477
9. Nagai N, Mushiga Y, Ozawa Y. Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography. Sci Rep. 2023;13(1):13809. doi:10.1038/s41598-023-40686-5
10. Sasaki M, Yuki K, Hanyuda A, Yamagishi K, Motomura K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Sawada N, Negishi K, Tsubota K, Tsugane S, Iso H. Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Sci Rep. 2023;13(1):12903. doi:10.1038/s41598-023-39734-x
11. Ozawa Y, Ohgami K, Sasaki K, Hirano K, Sunaya T. Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration. Sci Rep. 2023;13(1):10597. doi:10.1038/s41598-023-37584-1
12. Nagai N, Mushiga Y, Ozawa Y. Retinal Pigment Epithelial Abnormality and Choroidal Large Vascular Flow Imbalance Are Associated with Choriocapillaris Flow Deficits in Age-Related Macular Degeneration in Fellow Eyes. J Clin Med. 2023;12(4):1360. doi:10.3390/jcm12041360
13. Yasukawa T, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Yamagishi K, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H. Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population: JPHC-NEXT Eye Study. Transl Vis Sci Technol. 2023;12(1):3. doi:10.1167/tvst.12.1.3
14. Mushiga Y, Nagai N, Ozawa Y. Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics. Sci Rep. 2022;12(1):17457. doi:10.1038/s41598-022-21117-3
15. Yasukawa T, Hanyuda A, Yamagishi K, Yuki K, Uchino M, Ozawa Y, Sasaki M, Tsubota K, Sawada N, Negishi K, Tsugane S, Iso H. Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study. Sci Rep. 2022;12(1):17493. doi:10.1038/s41598-022-22301-1
16. Aichi R, Nagai N, Ohkoshi K, Ozawa Y. Impact of Treating Age-Related Macular Degeneration before Visual Function Is Impaired. J Clin Med. 2022;11(19):5726. doi:10.3390/jcm11195726
17. Harada N, Nagai N, Mushiga Y, Ozawa Y. Choriocapillaris Flow Imbalance in Fellow Eyes in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2022;63(9):13. doi:10.1167/iovs.63.9.13
18. Ozawa Y, Toda E, Homma K, Osada H, Nagai N, Tsubota K, Okano H. Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa. Cells. 2022;11(9):1497. doi:10.3390/cells11091497
19. Ofuji Y, Katada Y, Tomita Y, Nagai N, Sonobe H, Watanabe K, Shinoda H, Ozawa Y, Negishi K, Tsubota K, Kurihara T. Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy. Life (Basel). 2022;12(4):542. doi:10.3390/life12040542
20. Takei T, Nagai N, Ohkoshi K, Ozawa Y. Arm-to-retina time predicts visual outcome of anti-vascular endothelial growth factor treatment for macular edema due to central retinal vein occlusion. Sci Rep. 2022;12(1):2194. doi:10.1038/s41598-022-06281-w
21. Mushiga Y, Komoto T, Nagai N, Ozawa Y. Effects of intraocular treatments for Epstein-Barr virus (EBV) retinitis: A case report. Medicine (Baltimore). 2021;100(48):e28101. doi:10.1097/MD.0000000000028101
22. Akino K, Nagai N, Watanabe K, Ban N, Kurihara T, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane. Br J Ophthalmol. 2021;105(12):1683-1687. doi:10.1136/bjophthalmol-2020-317478
23. Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y. Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion. J Clin Med. 2021;10(17):3944. doi:10.3390/jcm10173944
24. Nakamura K, Honda R, Soeda S, Nagai N, Takahashi O, Kadonosono K, Ozawa Y. Factors associated with achieving intraocular pressure lower than 15 mmHg by Trabectome surgery in primary open-angle glaucoma. Sci Rep. 2021;11(1):14308. doi:10.1038/s41598-021-93711-w
25. Mendoza NAG, Homma K, Osada H, Toda E, Ban N, Nagai N, Negishi K, Tsubota K, Ozawa Y. Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina. Antioxidants (Basel). 2021;10(7):1147. doi:10.3390/antiox10071147
26. Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, Ozawa Y. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Cell Death Dis. 2021;12(5):458. doi:10.1038/s41419-021-03741-5
27. Shinojima A, Ozawa Y, Uchida A, Nagai N, Shinoda H, Kurihara T, Suzuki M, Minami S, Negishi K, Tsubota K. Assessment of Hypofluorescent Foci on Late-Phase Indocyanine Green Angiography in Central Serous Chorioretinopathy. J Clin Med. 2021;10(10):2178. doi:10.3390/jcm10102178
28. Aketa N, Uchino M, Kawashima M, Uchino Y, Yuki K, Ozawa Y, Sasaki M, Yamagishi K, Sawada N, Tsugane S, Tsubota K, Iso H. Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study. Sci Rep. 2021;11(1):6366. doi:10.1038/s41598-021-85617-4
29. Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y. Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium. Redox Biol. 2021;41:101921. doi:10.1016/j.redox.2021.101921
30. Minowa Y, Ohkoshi K, Ozawa Y. Subthreshold Laser Treatment for Serous Retinal Detachment Associated with Tilted Disc Syndrome. Case Rep Ophthalmol. 2021;12(3):978-986. doi:10.1159/000520570
31. Mori T, Kikuchi T, Koh M, Koda Y, Yamazaki R, Sakurai M, Tomita Y, Ozawa Y, Kohashi S, Abe R, Saburi M, Kato J. Cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation under cytomegalovirus antigenemia-guided active screening. Bone Marrow Transplant. 2021;56(6):1266-1271. doi:10.1038/s41409-020-01176-8
32. Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman NA, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y. Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Commun Biol. 2020;3(1):767. doi:10.1038/s42003-020-01483-2
33. Sato M, Minami S, Nagai N, Suzuki M, Kurihara T, Shinojima A, Sonobe H, Akino K, Ban N, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Association between axial length and choroidal thickness in early age-related macular degeneration. PLoS One. 2020;15(10):e0240357. doi:10.1371/journal.pone.0240357
34. Ozawa Y. Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration. Redox Biol. 2020;37:101779. doi:10.1016/j.redox.2020.101779
35. Asato T, Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y. Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment. Lasers Med Sci. 2021;36(2):469-471. doi:10.1007/s10103-020-03133-9
36. Mushiga Y, Minami S, Uchida A, Nagai N, Suzuki M, Kurihara T, Sonobe H, Ban N, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome. J Clin Med. 2020;9(8):2394. doi:10.3390/jcm9082394
37. Minami S, Nagai N, Suzuki M, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Ocular and Systemic Effects of Antioxidative Supplement Use in Young and Healthy Adults: Real-World Cross-Sectional Data. Antioxidants (Basel). 2020;9(6):487. doi:10.3390/antiox9060487

38. Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y. The Area and Number of Intraretinal Cystoid Spaces Predict the Visual Outcome after Ranibizumab Monotherapy in Diabetic Macular Edema. J Clin Med. 2020;9(5):1391. doi:10.3390/jcm9051391
39. Nagai N, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y. Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration. J Clin Med. 2020;9(5):1347. doi:10.3390/jcm9051347
40. Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y. Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina. Nutrients. 2020;12(4):888. doi:10.3390/nu12040888
41. Suzumura A, Kaneko H, Funahashi Y, Takayama K, Nagaya M, Ito S, Okuno T, Hirakata T, Nonobe N, Kataoka K, Shimizu H, Namba R, Yamada K, Ye F, Ozawa Y, Yokomizo T, Terasaki H. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy. Diabetes. 2020;69(4):724-735. doi:10.2337/db19-0550
42. Hanyuda A, Sawada N, Yuki K, Uchino M, Ozawa Y, Sasaki M, Yamagishi K, Iso H, Tsubota K, Tsugane S. Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study. Sci Rep. 2020;10(1):5355. doi:10.1038/s41598-020-62135-3
43. Kawashima H, Ozawa Y, Toda E, Homma K, Osada H, Narimatsu T, Nagai N, Tsubota K. Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator. FASEB J. 2020;34(4):5016-5026. doi:10.1096/fj.201902387RR
44. Ozawa Y, Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Uehara T, Kawakami S, Fujita A, Fujinaga Y, Oguchi K, Kawa S, Hanaoka M. A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis. Nagoya J Med Sci. 2020;82(1):101-111. doi:10.18999/nagjms.82.1.101
45. Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H. Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study. Sci Rep. 2020;10(1):779. doi:10.1038/s41598-019-57260-7
46. Saito S, Tanaka R, Sasaki T, Aoki S, Yasuhara R, Nakayama Y, Nagai T, Sonobe H, Ozawa Y, Kubo A. Subclinical hypopigmentation of the skin and hair in a Japanese patient with Hermansky-Pudlak syndrome type 3. J Dermatol. 2020;47(1):e18-e20. doi:10.1111/1346-8138.15118
47. Suzuki M, Nagai N, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy. Graefes Arch Clin Exp Ophthalmol. 2020;258(1):49-56. doi:10.1007/s00417-019-04495-9
48. Minami S, Shinoda H, Shigeno Y, Nagai N, Kurihara T, Watanabe K, Sonobe H, Takagi H, Tsubota K, Ozawa Y. Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy. Sci Rep. 2019;9:19056. doi:10.1038/s41598-019-55544-6
49. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Takagi H, Tsubota K, Ozawa Y. Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults. Sci Rep. 2019;9:18119. doi:10.1038/s41598-019-54606-z
50. Ozawa Y, Shinoda H, Nagai N, Tsubota K. Dynamic changes in neural retinal images during the development of a lamellar macular hole: A case report. Medicine (Baltimore). 2019;98(49):e18297. doi:10.1097/MD.0000000000018297
51. Ozawa Y, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K. Aquaporin 4 Suppresses Neural Hyperactivity and Synaptic Fatigue and Fine-Tunes Neurotransmission to Regulate Visual Function in the Mouse Retina. Mol Neurobiol. 2019;56(12):8124-8135. doi:10.1007/s12035-019-01661-2
52. Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K. High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study. J Clin Med. 2019;8(11):1788. doi:10.3390/jcm8111788
53. Okamoto T, Kawashima H, Osada H, Toda E, Homma K, Nagai N, Imai Y, Tsubota K, Ozawa Y. Dietary Spirulina Supplementation Protects Visual Function From Photostress by Suppressing Retinal Neurodegeneration in Mice. Transl Vis Sci Technol. 2019;8(6):20. doi:10.1167/tvst.8.6.20
54. Mimura R, Mori K, Torii H, Nagai N, Suzuki M, Minami S, Ozawa Y, Kurihara T, Tsubota K. Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma. J Clin Med. 2019;8(10):1505. doi:10.3390/jcm8101505
55. Nagai N, Suzuki M, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y. Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy. Sci Rep. 2019;9:11389. doi:10.1038/s41598-019-47738-9
56. Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y. QD laser eyewear as a visual field aid in a visual field defect model. Sci Rep. 2019;9:1010. doi:10.1038/s41598-018-37744-8
57. Hayashi I, Shinoda H, Nagaia N, Tsubota K, Ozawa Y. Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: A case report. Medicine (Baltimore). 2019;98(4):e14230. doi:10.1097/MD.0000000000014230
58. Kawashima H, Nagai N, Shinoda H, Tsubota K, Ozawa Y. Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. Medicine (Baltimore). 2018;97(17):e0321. doi:10.1097/MD.0000000000010321
59. Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y. Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline. Sci Rep. 2018;8:58. doi:10.1038/s41598-017-18255-4
60. Ozawa Y, Shigeno Y, Nagai N, Suzuki M, Kurihara T, Minami S, Hirano E, Shinoda H, Kobayashi S, Tsubota K. Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration. BMC Ophthalmol. 2017;17:161. doi:10.1186/s12886-017-0557-5
61. Osada H, Okamoto T, Kawashima H, Toda E, Miyake S, Nagai N, Kobayashi S, Tsubota K, Ozawa Y. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One. 2017;12(6):e0178627. doi:10.1371/journal.pone.0178627
62. Nagai N, Ibuki M, Shinoda H, Kameyama K, Tsubota K, Ozawa Y. Maculopapular rash after intravitreal injection of an antivascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report. Medicine (Baltimore). 2017;96(21):e6965. doi:10.1097/MD.0000000000006965
63. Sato S, Shinoda H, Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Tomita Y, Iyama C, Minami S, Yuki K, Tsubota K, Ozawa Y. Predictive factors of better outcomes by monotherapy of an antivascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice. Medicine (Baltimore). 2017;96(16):e6459. doi:10.1097/MD.0000000000006459
64. Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K. Novel RP1L1 Variants and Genotype-Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2016;57(11):4837-4846. doi:10.1167/iovs.16-19670
65. Nagai N, Ohta Y, Izumi-Nagai K, Shinoda H, Tsubota K, Ozawa Y. Sneddon's syndrome with optic disc macroaneurysm and macular edema successfully treated with subtenon steroid injection. Acta Ophthalmol. 2016;94(6):e517-e519. doi:10.1111/aos.12909
66. Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y. Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy With Single or Multiple Polyps: REPLY. Am J Ophthalmol. 2016;169:295-296. doi:10.1016/j.ajo.2016.06.018
67. Kamoshita M, Toda E, Osada H, Narimatsu T, Kobayashi S, Tsubota K, Ozawa Y. Lutein acts via multiple antioxidant pathways in the photo-stressed retina. Sci Rep. 2016;6:30226. doi:10.1038/srep30226
68. Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y. Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment. Sci Rep. 2016;6:29619. doi:10.1038/srep29619
69. Kamoshita M, Fujinami K, Toda E, Tsubota K, Ozawa Y. Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation. BMC Neurosci. 2016;17:32. doi:10.1186/s12868-016-0268-5
70. Masaki Y, Kawabata H, Takai K, Kojima M, Tsukamoto N, Ishigaki Y, Kurose N, Ide M, Murakami J, Nara K, Yamamoto H, Ozawa Y, Takahashi H, Miura K, Miyauchi T, Yoshida S, Momoi A, Awano N, Ikushima S, Ohta Y, Furuta N, Fujimoto S, Kawanami H, Sakai T, Kawanami T, Fujita Y, Fukushima T, Nakamura S, Kinoshita T, Aoki S. Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version. Int J Hematol. 2016;103(6):686-692. doi:10.1007/s12185-016-1979-1
71. Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y. Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy With Single or Multiple Polyps. Am J Ophthalmol. 2016;166:52-59. doi:10.1016/j.ajo.2016.03.024
72. Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y. Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration. J Biol Chem. 2016;291(14):7373-7385. doi:10.1074/jbc.M115.710186
73. Okamoto T, Ozawa Y, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K. The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation. PLoS One. 2016;11(1):e0146517. doi:10.1371/journal.pone.0146517
74. Tomita Y, Nagai N, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y. Functional Visual Acuity in Age-Related Macular Degeneration. Optom Vis Sci. 2016;93(1):70-76. doi:10.1097/OPX.0000000000000755
75. Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y. Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling. Sci Rep. 2015;5:13256. doi:10.1038/srep13256
76. Ozawa Y, Koto T, Shinoda H, Tsubota K. Vision Loss by Central Retinal Vein Occlusion After Kaatsu Training: A Case Report. Medicine (Baltimore). 2015;94(36):e1515. doi:10.1097/MD.0000000000001515
77. Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y. ASSOCIATION OF MACULAR PIGMENT OPTICAL DENSITY WITH SERUM CONCENTRATION OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEALTHY ADULTS. Retina. 2015;35(4):820-826. doi:10.1097/IAE.0000000000000382
78. Yotsukura-Tsutsui E, Koto T, Tsubota K, Ozawa Y. Predisposing factors for intraocular lens dislocation treated by pars plana vitrectomy: Involvement of atopic dermatitis. J Cataract Refract Surg. 2015;41(4):892-894. doi:10.1016/j.jcrs.2014.12.047
79. Narimatsu T, Negishi K, Miyake S, Hirasawa M, Osada H, Kurihara T, Tsubota K, Ozawa Y. Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo. Exp Eye Res. 2015;132:48-51. doi:10.1016/j.exer.2015.01.003
80. Ono T, Yuki K, Awano-Tanabe S, Fukagawa K, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Driving Self-restriction and Motor Vehicle Collision Occurrence in Glaucoma. Optom Vis Sci. 2015;92(3):357-364. doi:10.1097/OPX.0000000000000493
81. Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Robson AG, Holder GE, Allikmets R, Michaelides M, Moore AT. Clinical and Molecular Characteristics of Childhood-Onset Stargardt Disease. Ophthalmology. 2015;122(2):326-334. doi:10.1016/j.ophtha.2014.08.012
82. Kamoshita M, Matsumoto Y, Nishimura K, Katono Y, Murata M, Ozawa Y, Shimmura S, Tsubota K. Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin. J Infect Chemother. 2015;21(1-2):141-143. doi:10.1016/j.jiac.2014.08.019
83. Ono T, Yuki K, Asaoka R, Kouyama K, Abe T, Tanabe S, Fukagawa K, Uchino M, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K. Glaucomatous Visual Field Defect Severity and the Prevalence of Motor Vehicle Collisions in Japanese: A Hospital/Clinic-Based Cross-Sectional Study. J Ophthalmol. 2015;2015:497067. doi:10.1155/2015/497067
84. Nagai N, Kubota S, Tsubota K, Ozawa Y. Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types. J Nutr Biochem. 2014;25(11):1218-1225. doi:10.1016/j.jnutbio.2014.05.015
85. Okamoto T, Shinoda H, Kurihara T, Nagai N, Tsubota K, Ozawa Y. Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy. BMC Ophthalmol. 2014;14:114. doi:10.1186/1471-2415-14-114
86. Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K, Ozawa Y. Predictive factors for non-response to intravitreal ranibizumab treatment in age-related macular degeneration. Br J Ophthalmol. 2014;98(9):1186-1191. doi:10.1136/bjophthalmol-2013-304670
87. Narimatsu T, Ozawa Y, Miyake S, Kubota S, Yuki K, Nagai N, Tsubota K. Biological effects of blocking blue and other visible light on the mouse retina. Clin Experiment Ophthalmol. 2014;42(6):555-563. doi:10.1111/ceo.12253
88. Sasaki M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Wong TY, Ozawa Y. Early Signs of Exudative Age-Related Macular Degeneration in Asians. Optom Vis Sci. 2014;91(8):849-853. doi:10.1097/OPX.0000000000000317
89. Kamoshita M, Ozawa Y, Kubota S, Miyake S, Tsuda C, Nagai N, Yuki K, Shimmura S, Umezawa K, Tsubota K. AMPK-NF-κB Axis in the Photoreceptor Disorder during Retinal Inflammation. PLoS One. 2014;9(7):e103013. doi:10.1371/journal.pone.0103013
90. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain. 2014;7:45. doi:10.1186/1756-6606-7-45
91. Narimatsu T, Ozawa Y, Miyake S, Nagai N, Tsubota K. Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina. Free Radic Biol Med. 2014;71:176-185. doi:10.1016/j.freeradbiomed.2014.03.020
92. Miyake S, Kobayashi S, Tsubota K, Ozawa Y. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line. Biochem Biophys Res Commun. 2014;446(2):535-540. doi:10.1016/j.bbrc.2014.02.135
93. Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Wang JJ, Ozawa Y. Association of Serum Lipids With Macular Thickness and Volume in Type 2 Diabetes Without Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2014;55(3):1749-1753. doi:10.1167/iovs.13-13035
94. Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y. VITRECTOMY FOR MYOPIC FOVEOSCHISIS WITH INTERNAL LIMITING MEMBRANE PEELING AND NO GAS TAMPONADE. Retina. 2014;34(3):455-460. doi:10.1097/IAE.0b013e3182a0e477
95. Uchida A, Miwa M, Shinoda H, Koto T, Nagai N, Mochimaru H, Tomita Y, Sasaki M, Ikeda K, Tsubota K, Ozawa Y. Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks. J Ophthalmol. 2014;2014:187929. doi:10.1155/2014/187929
96. Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S. Atp6ap2/(Pro)renin Receptor Interacts with Par3 as a Cell Polarity Determinant Required for Laminar Formation during Retinal Development in Mice. J Neurosci. 2013;33(49):19341-19351. doi:10.1523/JNEUROSCI.1362-13.2013
97. Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013;48(11):1212-1217. doi:10.1016/j.exger.2013.04.010
98. Yuki K, Tanabe S, Kouyama K, Fukagawa K, Uchino M, Shimoyama M, Ozeki N, Shiba D, Ozawa Y, Abe T, Tsubota K. The Association Between Visual Field Defect Severity and Fear of Falling in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2013;54(12):7739-7745. doi:10.1167/iovs.13-12079
99. Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Webster AR, Moore AT, Allikmets R, Michaelides M. ABCA4 Gene Screening by Next-Generation Sequencing in a British Cohort. Invest Ophthalmol Vis Sci. 2013;54(10):6662-6674. doi:10.1167/iovs.13-12570
100. Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol. 2013;48(10):1096-1100. doi:10.1016/j.exger.2013.04.002
101. Yuki K, Yoshida T, Miyake S, Tsubota K, Ozawa Y. Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-D-aspartate-induced cytotoxicity. Exp Eye Res. 2013;115:230-238. doi:10.1016/j.exer.2013.07.002
102. Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y. Detection of early visual impairment in patients with epiretinal membrane. Acta Ophthalmol. 2013;91(5):e353-e357. doi:10.1111/aos.12060
103. Yoshikawa N, Noda K, Ozawa Y, Mashima Y, Ishida S. Blockade for vascular adhesion protein-1 suppresses pathological neovascularization in oxygen-induced retinopathy. Acta Ophthalmol. 2013;91(5):e409-e410. doi:10.1111/aos.12128
104. Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y. Molecular characteristics of four Japanese cases with KCNV2 retinopathy: Report of novel disease-causing variants. Mol Vis. 2013;19:1580-1590.
105. Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K. Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice. Invest Ophthalmol Vis Sci. 2013;54(7):4555-4562. doi:10.1167/iovs.12-11572
106. Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K. Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease. PLoS One. 2013;8(6):e64724. doi:10.1371/journal.pone.0064724
107. Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Serum Vascular Adhesion Protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes. J Diabetes Complications. 2013;27(2):162-166. doi:10.1016/j.jdiacomp.2012.09.001
108. Ozawa Y, Yuki K, Yamagishi R, Tsubota K, Aihara M. Renin-angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells. Jpn J Ophthalmol. 2013;57(1):126-132. doi:10.1007/s10384-012-0204-x
109. Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K. Presence and Physiologic Function of the Renin-Angiotensin System in Mouse Lacrimal Gland. Invest Ophthalmol Vis Sci. 2012;53(9):5416-5425. doi:10.1167/iovs.12-9891
110. Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S. Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2012;53(7):4055-4062. doi:10.1167/iovs.12-9857
111. Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y. Biological role of lutein in the light-induced retinal degeneration. J Nutr Biochem. 2012;23(5):423-429. doi:10.1016/j.jnutbio.2011.01.006
112. Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S. Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization. Mol Vis. 2012;18:593-600.
113. Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol. 2012;363(1):106-114. doi:10.1016/j.ydbio.2011.12.027
114. Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y. Use of Micronutrient Supplement for Preventing Advanced Age-Related Macular Degeneration in Japan. Arch Ophthalmol. 2012;130(2):254-255. doi:10.1001/archopthalmol.2011.1368
115. Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Lab Invest. 2012;92(1):102-109. doi:10.1038/labinvest.2011.132
116. Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K. Neuroprotective Effects of Lutein in the Retina. Curr Pharm Des. 2012;18(1):51-56. doi:10.2174/138161212798919101
117. Suzuki M, Ozawa Y, Kubota S, Hirasawa M, Miyake S, Noda K, Tsubota K, Kadonosono K, Ishida S. Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor. J Neuroinflammation. 2011;8:176. doi:10.1186/1742-2094-8-176
118. Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K. Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation. Invest Ophthalmol Vis Sci. 2011;52(12):9142-9148. doi:10.1167/iovs.11-8041
119. Yuki K, Ozawa Y, Yoshida T, Kurihara T, Hirasawa M, Ozeki N, Shiba D, Noda K, Ishida S, Tsubota K. Retinal Ganglion Cell Loss in Superoxide Dismutase 1 Deficiency. Invest Ophthalmol Vis Sci. 2011;52(7):4143-4150. doi:10.1167/iovs.10-6294
120. Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, Inoue M, Ogawa Y, Tsubota K, Ishida S. Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization. Mol Vis. 2011;17:1222-1230.
121. Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y. Clinical Findings in a Choroideremia Patient Who Underwent Vitrectomy for Retinal Detachment Associated with Macular Hole. Jpn J Ophthalmol. 2011;55(2):169-171. doi:10.1007/s10384-010-0911-0
122. Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal Alkali-Burn Model. Invest Ophthalmol Vis Sci. 2011;52(1):427-433. doi:10.1167/iovs.10-6167
123. Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K. Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model. Exp Diabetes Res. 2011:108328. doi:10.1155/2011/108328
124. Ozawa Y, Kurihara T, Tsubota K, Okano H. Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection. J Ophthalmol. 2011;2011:506137. doi:10.1155/2011/506137
125. Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation. Am J Pathol. 2010;177(4):1725-1731. doi:10.2353/ajpath.2010.100098
126. Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S. Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. Mol Vis. 2010;16:1382-1388.
127. Tomita Y, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy. Jpn J Ophthalmol. 2010;54(4):366-368. doi:10.1007/s10384-010-0823-z
128. Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010;137(9):1563-1571. doi:10.1242/dev.049015
129. Ozawa Y, Kubota S, Narimatsu T, Yuki K, Koto T, Sasaki M, Tsubota K. Retinal Aging and Sirtuins. Ophthalmic Res. 2010;44(3):199-203. doi:10.1159/000316484
130. Sugisaka E, Shinoda K, Sano RY, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Mechanism of Visual Sensations Experienced during Pars Plana Vitrectomy under Retrobulbar Anesthesia. Ophthalmologica. 2010;224(2):103-108. doi:10.1159/000235858
131. Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K. Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis. 2009;15:2751-2761.
132. Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K. Involvement of Hyaluronan and Its Receptor CD44 with Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2009;50(9):4410-4415. doi:10.1167/iovs.08-3044
133. Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K. Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-κB Activation. Invest Ophthalmol Vis Sci. 2009;50(7):3512-3519. doi:10.1167/iovs.08-2666
134. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin Receptor-Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation. Diabetes. 2009;58(7):1625-1633. doi:10.2337/db08-0254
135. Hirasawa M, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S. Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection. Jpn J Ophthalmol. 2009;53(3):279-281. doi:10.1007/s10384-009-0665-8
136. Sasaki M, Ozawa Y, Kurihara T, Noda K, Imamura Y, Kobayashi S, Ishida S, Tsubota K. Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation. Invest Ophthalmol Vis Sci. 2009;50(3):1433-1439. doi:10.1167/iovs.08-2493
137. Susaki K, Kaneko J, Yamano Y, Nakamura K, Inami W, Yoshikawa T, Ozawa Y, Shibata S, Matsuzaki O, Okano H, Chiba C. Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp Eye Res. 2009;88(3):347-355. doi:10.1016/j.exer.2008.06.019
138. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S. (Pro)renin Receptor Promotes Choroidal Neovascularization by Activating Its Signal Transduction and Tissue Renin-Angiotensin System. Am J Pathol. 2008;173(6):1911-1918. doi:10.2353/ajpath.2008.080457
139. Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H. Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. J Biol Chem. 2008;283(36):24561-24570. doi:10.1074/jbc.M802238200
140. Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y, Ishida S. Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina. Diabetes. 2008;57(8):2191-2198. doi:10.2337/db07-1281
141. Hashizume K, Hirasawa M, Imamura Y, Noda S, Shimizu T, Shinoda K, Kurihara T, Noda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K. Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice. Am J Pathol. 2008;172(5):1325-1331. doi:10.2353/ajpath.2008.070730
142. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci. 2008;49(4):1679-1685. doi:10.1167/iovs.07-1426
143. Shinoda H, Shinoda K, Satofuka S, Imamura Y, Ozawa Y, Ishida S, Inoue M. Visual recovery after vitrectomy for macular hole using 25-gauge instruments. Acta Ophthalmol. 2008;86(2):151-155. doi:10.1111/j.1600-0420.2007.01000.x
144. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S, Oike Y, Ishida S. Macular pigment lutein is antiinflammatory in preventing Choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2007;27(12):2555-2562. doi:10.1161/ATVBAHA.107.151431
145. Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T, Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S. Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2. Invest Ophthalmol Vis Sci. 2007;48(10):4795-4801. doi:10.1167/iovs.07-0425
146. Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(9):4328-4334. doi:10.1167/iovs.06-1148
147. Nagai N, Izumi-Nagai K, Oike Y, Koto T, Satofuka S, Ozawa Y, Yamashiro K, Inoue M, Tsubota K, Umezawa K, Ishida S. Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-κB pathway. Invest Ophthalmol Vis Sci. 2007;48(9):4342-4350. doi:10.1167/iovs.06-1473
148. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M. Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia. Am J Ophthalmol. 2007;144(2):245-251. doi:10.1016/j.ajo.2007.05.001
149. Izumi-Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, Koto T, Satofuka S, Inoue M, Tsubota K, Okano H, Oike Y, Ishida S. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170(6):2149-2158. doi:10.2353/ajpath.2007.061018
150. Nagai N, Oike Y, Izumi-Nagai K, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Ishida S. Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: Minimal role of bradykinin. Invest Ophthalmol Vis Sci. 2007;48(5):2321-2326. doi:10.1167/iovs.06-1296
151. Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H. SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007;303(2):591-600. doi:10.1016/j.ydbio.2006.11.032
152. Satofuka S, Ichihara A, Nagai N, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Itoh H, Oike Y, Ishida S. Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization. Invest Ophthalmol Vis Sci. 2007;48(1):422-429. doi:10.1167/iovs.06-0534
153. Kurihara T, Ozawa Y, Shinoda K, Nagai N, Inoue M, Oike Y, Tsubota K, Ishida S, Okano H. Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest Ophthalmol Vis Sci. 2006;47(12):5545-5552. doi:10.1167/iovs.06-0478
154. Nagai N, Oike Y, Izumi-Nagai K, Urano T, Kubota Y, Noda K, Ozawa Y, Inoue M, Tsubota K, Suda T, Ishida S. Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2006;26(10):2252-2259. doi:10.1161/01.ATV.0000240050.15321.fe
155. Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Nakajima T, Shinoda H, Suzuki K, Kawaguchi N, Inoue M. Visual sensations during vitrectomy. Ophthalmology. 2006;113(10):1886-1887.
156. Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006;47(6):2686-2692. doi:10.1167/iovs.05-1458