1. Hirayama M, Hatou S, Nomura M, Hokama R, Hirayama OI, Inagaki E, Aso K, Sayano T, Dohi H, Hanatani T, Takasu N, Okano H, Negishi K, Shimmura S. One year course of a first-in-human clinical study of an allogenic iPSC-derived corneal endothelial cell substitute transplantation for bullous keratopathy. Cell Reports Medicine. 2025;6(1):101847. doi:10.1016/j.celrep.2024.101847
2. Rusch R, Inagaki E, Taniguchi H, Sakakura S, Tamai R, Nonaka H, Shimizu S, Sato S, Ogawa Y, Hirayama M, Negishi K, Okano H, Shimmura S. Adipose-Derived Mesenchymal Stromal Cells: A Study on Safety and Efficacy in Ocular Inflammation. The Ocular Surface. 2024. doi:10.1016/j.jcms.2024.11.002
3. Sakakura S, Yamazaki R, Uchino Y, Negishi K, Shimmura S. Non-Descemet stripping endothelial keratoplasty for bullous keratopathy in patients with atopic dermatitis: A long-term case report. Medicine (Baltimore). 2024;103(39):e39665. doi:10.1097/MD.0000000000039665
4. Asai K, Lee HK, Sato S, Shimizu E, Jung J, Okazaki T, Ogawa M, Shimmura S, Tsubota K, Ogawa Y, Negishi K, Hirayama M. The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease. Invest Ophthalmol Vis Sci. 2024;65(10):38. doi:10.1167/iovs.65.10.38
5. Sato S, Ogawa Y, Shimizu E, Asai K, Okazaki T, Rusch R, Hirayama M, Shimmura S, Negishi K, Tsubota K. Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model. Ocul Surf. 2024;32:198-210. doi:10.1016/j.jcms.2024.03.003
6. Shimmura S, Inagaki E, Hirayama M, Hatou S. The Cornea: An Ideal Tissue for Regenerative Medicine. Keio J Med. 2024;73(1):1-7. doi:10.2302/kjm.73.1
7. Sakakura S, Inagaki E, Ochiai Y, Yamamoto M, Takai N, Nagata T, Higa K, Sato Y, Toshida H, Murat D, Hirayama M, Ogawa Y, Negishi K, Shimmura S. A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model. Int J Mol Sci. 2023;24(22):16048. doi:10.3390/ijms242216048
8. Altshuler A, Amitai-Lange A, Nasser W, Dimri S, Bhattacharya S, Tiosano B, Barbara R, Aberdam D, Shimmura S, Shalom-Feuerstein R. Eyes open on stem cells. Stem Cell Reports. 2023;18(12):2563-2565. doi:10.1016/j.stemcr.2023.11.002
9. Sakakura S, Inagaki E, Sayano T, Yamazaki R, Fusaki N, Hatou S, Hirayama M, Tsubota K, Negishi K, Okano H, Shimmura S. Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy. Regen Ther. 2023;24:592-601. doi:10.1016/j.reth.2023.08.002
10. Terai H, Ishii M, Takemura R, Namkoong H, Shimamoto K, Masaki K, Tanosaki T, Chubachi S, Matsuyama E, Hayashi R, Shimada T, Shigematsu L, Ito F, Kaji M, Takaoka H, Kurihara M, Nakagawara K, Tomiyasu S, Sasahara K, Saito A, Otake S, Azekawa S, Okada M, Fukushima T, Morita A, Tanaka H, Sunata K, Asaoka M, Nishie M, Shinozaki T, Ebisudani T, Akiyama Y, Mitsuishi A, Nakayama S, Ogawa T, Sakurai K, Irie M, Yagi K, Ohgino K, Miyata J, Kabata H, Ikemura S, Kamata H, Yasuda H, Kawada I, Kimura R, Kondo M, Iwasaki T, Ishida N, Hiruma G, Miyazaki N, Ishibashi Y, Harada S, Fujita T, Ito D, Bun S, Tabuchi H, Kanzaki S, Shimizu E, Fukuda K, Yamagami J, Kobayashi K, Hirano T, Inoue T, Haraguchi M, Kagyo J, Shiomi T, Lee H, Sugihara K, Omori N, Sayama K, Otsuka K, Miyao N, Odani T, Watase M, Mochimaru T, Satomi R, Oyamada Y, Masuzawa K, Asakura T, Nakayama S, Suzuki Y, Baba R, Okamori S, Arai D, Nakachi I, Kuwahara N, Fujiwara A, Oakada T, Ishiguro T, Isosno T, Makino Y, Mashimo S, Kaido T, Minematsu N, Ueda S, Minami K, Hagiwara R, Manabe T, Fukui T, Funatsu Y, Koh H, Yoshiyama T, Kokuto H, Kusumoto T, Oashi A, Miyawaki M, Saito F, Tani T, Ishioka K, Takahashi S, Nakamura M, Harada N, Sasano H, Goto A, Kusaka Y, Ohba T, Nakano Y, Nishio K, Nakajima Y, Suzuki S, Yoshida S, Tateno H, Kodama N, Shunsuke M, Sakamoto S, Okamoto M, Nagasaki Y, Umeda A, Miyagawa K, Shimada H, Hagimura K, Nagashima K, Sato T, Sato Y, Hasegawa N, Takebayashi T, Nakahara J, Mimura M, Ogawa K, Shimmura S, Negishi K, Tsubota K, Amagai M, Goto R, Ibuka Y, Kitagawa Y, Kanai T, Fukunaga K. Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study. Respir Investig. 2023;61(6):802-814. doi:10.1016/j.resinv.2023.08.002
11. Shimizu E, Sato S, Asai K, Ogawa Y, Shimmura S, Negishi K. Clinical Features of Sjogren Syndrome-Related Dry Eye Disease in Anterior Segment Photographs. Cornea. 2023;42(10):1314-1322. doi:10.1097/ICO.0000000000000407
12. Hatou S, Shimmura S. Advances in corneal regenerative medicine with iPS cells. Jpn J Ophthalmol. 2023;67(5):541-545. doi:10.1007/s10384-023-01017-9
13. Matsumae H, Yamaguchi T, Kusano Y, Shimmura S, Kobayashi A, Morizane Y, Shimazaki J. Graft Size and Double Scroll Formation Rate in Descemet Membrane Endothelial Keratoplasty. Curr Eye Res. 2022;47(9):1246-1251. doi:10.1080/02713683.2022.2070438
14. Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S. The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests. Stem Cells Transl Med. 2022;11(8):841-849. doi:10.1002/sctm.22-0046
15. Shimizu S, Sato S, Taniguchi H, Shimizu E, He J, Hayashi S, Negishi K, Ogawa Y, Shimmura S. Observation of Chronic Graft-Versus-Host Disease Mouse Model Cornea with In Vivo Confocal Microscopy. Diagnostics (Basel). 2021;11(8):1377. doi:10.3390/diagnostics11081377
16. Rusch RM, Ogawa Y, Sato S, Morikawa S, Inagaki E, Shimizu E, Tsubota K, Shimmura S. MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation. Int J Mol Sci. 2021;22(9):4870. doi:10.3390/ijms22094870
17. Nakagawara K, Namkoong H, Terai H, Masaki K, Tano-saki T, Shimamoto K, Lee H, Tanaka H, Okamori S, Kabata H, Chubachi S, Ikemura S, Kamata H, Yasuda H, Kawada I, Ishii M, Ishibashi Y, Harada S, Fujita T, Ito D, Bun S, Tabuchi H, Kanzaki S, Shimizu E, Fukuda K, Yamagami J, Kobayashi K, Hirano T, Inoue T, Kagyo J, Shiomi T, Ohgino K, Sayama K, Otsuka K, Miyao N, Odani T, Oyamada Y, Masuzawa K, Nakayama S, Suzuki Y, Baba R, Nakachi I, Kuwahara N, Ishiguro T, Mashimo S, Minematsu N, Ueda S, Manabe T, Funatsu Y, Koh H, Yoshiyama T, Saito F, Ishioka K, Takahashi S, Nakamura M, Goto A, Harada N, Kusaka Y, Nakano Y, Nishio K, Tateno H, Edahiro R, Takeda Y, Kumanogoh A, Kodama N, Okamoto M, Umeda A, Hagimura K, Sato T, Miyazaki N, Takemura R, Sato Y, Takebayashi T, Nakahara J, Mimura M, Ogawa K, Shimmura S, Negishi K, Tsubota K, Amagai M, Goto R, Ibuka Y, Hasegawa N, Kitagawa Y, Kanai T, Fukunaga K. Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol. BMJ Open Respir Res. 2021;8(1):e001150. doi:10.1136/bmjresp-2021-001150
18. Hatou S, Sayano T, Higa K, Inagaki E, Okano Y, Sato Y, Okano H, Tsubota K, Shimmura S. Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model. Stem Cell Res. 2021;55:102497. doi:10.1016/j.stemcr.2021.102497
19. Hata-Mizuno M, Uchino Y, Uchino M, Shimmura S, Ogawa Y, Tsubota K, Negishi K. Analysis of the Association between Galectin-3 Concentration in Tears and the Severity of Dry Eye Disease: A Case-Control Study. J Clin Med. 2021;11(1):257. doi:10.3390/jcm11010257
20. Yamazaki R, Nejima R, Ichihashi Y, Miyata K, Tsubota K, Shimmura S. Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy. Jpn J Ophthalmol. 2020;64(6):585-590. doi:10.1007/s10384-020-00787-w
21. Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J. 2020;34(8):10778-10800. doi:10.1096/fj.202000216R
22. Higa K, Higuchi J, Kimoto R, Miyashita H, Shimazaki J, Tsubota K, Shimmura S. Human corneal limbal organoids maintaining limbal stem cell niche function. Stem Cell Res. 2020;49:102012. doi:10.1016/j.stemcr.2020.102012
23. Hata-Mizuno M, Ingaki E, Mitamura H, Uchino Y, Tsubota K, Shimmura S. Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty. Cornea. 2020;39(9):1181-1183. doi:10.1097/ICO.0000000000002440
24. Yamashita K, Hatou S, Uchino Y, Tsubota K, Shimmura S. Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas. Jpn J Ophthalmol. 2019;63(1):56-64. doi:10.1007/s10384-018-0628-8
25. Venkatraman A, Hochart G, Bonnel D, Stauber J, Shimmura S, Rajamani L, Pervushin K, Mehta JS. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI-H626R and TGFBI-R124C Mutations. Proteomics Clin Appl. 2019;13(1):e1800053. doi:10.1002/prca.201800053
26. Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, Shimmura S, Sugita S. Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells. Stem Cells Dev. 2019;28(1):28-43. doi:10.1089/scd.2018.0125
27. Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE, G and The International Limbal Stem Cell Deficiency Working Group. Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea. 2019;38(3):364-375. doi:10.1097/ICO.0000000000001844
28. Yamashita K, Inagaki E, Hatou S, Higa K, Ogawa A, Miyashita H, Tsubota K, Shimmura S. Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord. Stem Cells Dev. 2018;27(16):1097-1108. doi:10.1089/scd.2018.0051
29. Yamashita K, Hatou S, Inagaki E, Higa K, Tsubota K, Shimmura S. A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells. Sci Rep. 2018;8(1):16868. doi:10.1038/s41598-018-35201-4
30. Yamane M, Ogawa Y, Mukai S, Yaguchi S, Kamijuku H, Inaba T, Asai K, Morikawa S, Kawakami Y, Shimmura S, Tsubota K. Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease. Cornea. 2018;37(1):102-108. doi:10.1097/ICO.0000000000001429
31. Den S, Shimmura S, Shimazaki J. Cataract surgery after deep anterior lamellar keratoplasty and penetrating keratoplasty in age- and disease-matched eyes. J Cataract Refract Surg. 2018;44(4):496-503. doi:10.1016/j.jcrs.2018.01.031
32. Yamazaki R, Yamazoe K, Yoshida S, Hatou S, Inagaki E, Okano H, Tsubota K, Shimmura S. The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model. Sci Rep. 2017;7(1):15584. doi:10.1038/s41598-017-15579-2
33. Shimmura-Tomita M, Shimmura S, Tsubota K, Shimazaki J. Penetrating Keratoplasty Performed by Residents Compared With an Experienced Cornea Transplant Surgeon. J Surg Educ. 2017;74(2):258-263. doi:10.1016/j.jsurg.2016.10.005
34. Miyashita H, Niwano H, Yoshida S, Hatou S, Inagaki E, Tsubota K, Shimmura S. Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model. Sci Rep. 2017;7:43557. doi:10.1038/srep43557
35. Inagaki E, Hatou S, Higa K, Yoshida S, Shibata S, Okano H, Tsubota K, Shimmura S. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration. Stem Cells Transl Med. 2017;6(3):788-798. doi:10.1002/sctm.16-0180
36. Hirayama M, Ko SBH, Kawakita T, Akiyama T, Goparaju SK, Soma A, Nakatake Y, Sakota M, Chikazawa-Nohtomi N, Shimmura S, Tsubota K, Ko MSH. Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells. NPJ Aging Mech Dis. 2017;3:1. doi:10.1038/s41514-017-0002-z
37. Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S. MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model. Elife. 2016;5:e09394. doi:10.7554/eLife.09394
38. Ogawa A, Matsumoto Y, Yaguchi T, Shimmura S, Tsubota K. Successful treatment of Beauveria bassiana fungal keratitis with topical voriconazole. J Infect Chemother. 2016;22(4):257-260. doi:10.1016/j.jiac.2015.12.001
39. Ishiyama S, Mori Y, Nejima R, Tokudome T, Shimmura S, Miyata K, Amano S. Comparison of Long-Term Outcomes of Visual Function and Endothelial Cell Survival After Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty Using Mixed-Effects Models. Cornea. 2016;35(2):161-167. doi:10.1097/ICO.0000000000000729
40. Hirayama M, Liu Y, Kawakita T, Shimmura S, Tsubota K. Cytokeratin expression in mouse lacrimal gland germ epithelium. Exp Eye Res. 2016;146:54-59. doi:10.1016/j.exer.2016.03.003
41. Yamazoe K, Yoshida S, Yasuda M, Hatou S, Inagaki E, Ogawa Y, Tsubota K, Shimmura S. Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2. PLoS One. 2015;10(7):e0133397. doi:10.1371/journal.pone.0133397
42. Yaguchi S, Ogawa Y, Kawakita T, Shimmura S, Tsubota K. Tissue Renin-Angiotensin System in Lacrimal Gland Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease. Cornea. 2015;34 Suppl 11:S142-152. doi:10.1097/ICO.0000000000000572
43. Kawakita T, Shimmura S, Tsubota K. Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjogren Syndrome. Asia Pac J Ophthalmol (Phila). 2015;4(2):101-105. doi:10.1097/APO.0000000000000085
44. Kamoshita M, Matsumoto Y, Nishimura K, Katono Y, Murata M, Ozawa Y, Shimmura S, Tsubota K. Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin. J Infect Chemother. 2015;21(2):141-143. doi:10.1016/j.jiac.2014.07.011
45. Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K. Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease. Mod Rheumatol. 2015;25(5):811-817. doi:10.3109/14397595.2014.992224
46. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain. 2014;7:45. doi:10.1186/1756-6606-7-45
47. Shiba D, Hatou S, Ono T, Hosoda S, Tanabe S, Ozeki N, Yuki K, Shimoyama M, Fukagawa K, Shimmura S, Tsubota K. Multivariable logistic regression model: a novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma. PLoS One. 2014;9(8):e104126. doi:10.1371/journal.pone.0104126
48. Satake Y, Yamaguchi T, Hirayama M, Higa K, Shimazaki-Den S, Dogru M, Kawakita T, Kawashima M, Shimmura S, Tsubota K, Shimazaki J. Ocular surface reconstruction by cultivated epithelial sheet transplantation. Cornea. 2014;33 Suppl 11:S42-46. doi:10.1097/ICO.0000000000000216
49. Kamoshita M, Ozawa Y, Kubota S, Miyake S, Tsuda C, Nagai N, Yuki K, Shimmura S, Umezawa K, Tsubota K. AMPK-NF-kappaB axis in the photoreceptor disorder during retinal inflammation. PLoS One. 2014;9(7):e103013. doi:10.1371/journal.pone.0103013
50. Fujii S, Matsumoto Y, Fukui M, Fujitake J, Kawakita T, Shimmura S, Tsubota K. Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal. Cornea. 2014;33(12):1320-1323. doi:10.1097/ICO.0000000000000259
51. Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K. Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS One. 2013;8(6):e64724. doi:10.1371/journal.pone.0064724
52. Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K. Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice. Invest Ophthalmol Vis Sci. 2013;54(7):4555-4562. doi:10.1167/iovs.13-11883
53. Miyashita H, Yokoo S, Yoshida S, Kawakita T, Yamagami S, Tsubota K, Shimmura S. Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor. Stem Cells Transl Med. 2013;2(10):758-765. doi:10.5966/sctm.2013-0010
54. Konomi K, Satake Y, Shimmura S, Tsubota K, Shimazaki J. Long-term results of amniotic membrane transplantation for partial limbal deficiency. Cornea. 2013;32(8):1110-1115. doi:10.1097/ICO.0b013e318288d227
55. Kawakita T, Kawabata F, Tsuji T, Kawashima M, Shimmura S, Tsubota K. Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial. Biomed Res. 2013;34(5):215-220. doi:10.2220/biomedres.34.215
56. Kawai M, Ogawa Y, Shimmura S, Ohta S, Suzuki T, Kawamura N, Kuwana M, Kawakami Y, Tsubota K. Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. Sci Rep. 2013;3:2455. doi:10.1038/srep02455
57. Inagaki E, Hatou S, Yoshida S, Miyashita H, Tsubota K, Shimmura S. Expression and distribution of claudin subtypes in human corneal endothelium. Invest Ophthalmol Vis Sci. 2013;54(12):7258-7265. doi:10.1167/iovs.13-12502
58. Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, Tsuji T. Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nat Commun. 2013;4:2497. doi:10.1038/ncomms3497
59. Higa K, Kato N, Yoshida S, Ogawa Y, Shimazaki J, Tsubota K, Shimmura S. Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium. Stem Cell Res. 2013;10(2):147-155. doi:10.1016/j.stemcr.2012.11.006
60. Hatou S, Yoshida S, Higa K, Miyashita H, Inagaki E, Okano H, Tsubota K, Shimmura S. Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/beta-catenin signaling. Stem Cells Dev. 2013;22(5):828-839. doi:10.1089/scd.2012.0305
61. Hatou S, Higa K, Inagaki E, Yoshida S, Kimura E, Hayashi R, Tsujikawa M, Tsubota K, Nishida K, Shimmura S. Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine. Tissue Eng Part C Methods. 2013;19(12):901-910. doi:10.1089/ten.tec.2012.0725
62. Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K. Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2012;53(9):5416-5425. doi:10.1167/iovs.12-9844
63. Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K. Oxidative stress induced inflammation initiates functional decline of tear production. PLoS One. 2012;7(10):e45805. doi:10.1371/journal.pone.0045805
64. Tatematsu Y, Ogawa Y, Shimmura S, Dogru M, Yaguchi S, Nagai T, Yamazaki K, Kameyama K, Okamoto S, Kawakami Y, Tsubota K. Mucosal microvilli in dry eye patients with chronic GVHD. Bone Marrow Transplant. 2012;47(3):416-425. doi:10.1038/bmt.2011.96
65. Ozeki N, Yuki K, Shiba D, Shimmura S, Murat D, Tsubota K. Intraocular pressure elevation after Descemet’s stripping endothelial keratoplasty. Jpn J Ophthalmol. 2012;56(4):307-311. doi:10.1007/s10384-012-0164-8
66. Omoto M, Yoshida S, Miyashita H, Kawakita T, Yoshida K, Kishino A, Kimura T, Shibata S, Tsubota K, Okano H, Shimmura S. The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model. PLoS One. 2012;7(11):e47716. doi:10.1371/journal.pone.0047716
67. Kobayashi S, Kawakita T, Kawashima M, Okada N, Mishima K, Saito I, Ito M, Shimmura S, Tsubota K. Characterization of cultivated murine lacrimal gland epithelial cells. Mol Vis. 2012;18:1271-1277.
68. Kawashima M, Kawakita T, Inaba T, Okada N, Ito M, Shimmura S, Watanabe M, Shinmura K, Tsubota K. Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice. PLoS One. 2012;7(3):e33148. doi:10.1371/journal.pone.0033148
69. Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K. Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren’s type dry eye in visual display terminal users. PLoS One. 2012;7(9):e43688. doi:10.1371/journal.pone.0043688
70. Yoshida S, Yasuda M, Miyashita H, Ogawa Y, Yoshida T, Matsuzaki Y, Tsubota K, Okano H, Shimmura S. Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells. PLoS One. 2011;6(12):e28856. doi:10.1371/journal.pone.0028856
71. Uchino Y, Shimmura S, Yamaguchi T, Kawakita T, Matsumoto Y, Negishi K, Tsubota K. Comparison of corneal thickness and haze in DSAEK and penetrating keratoplasty. Cornea. 2011;30(3):287-290. doi:10.1097/ICO.0b013e3181f08535
72. Shimazaki J, Den S, Omoto M, Satake Y, Shimmura S, Tsubota K. Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation. Am J Ophthalmol. 2011;152(1):33-39.e1. doi:10.1016/j.ajo.2011.01.019
73. Okada N, Kawakita T, Mishima K, Saito I, Miyashita H, Yoshida S, Shimmura S, Tsubota K. Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro. Invest Ophthalmol Vis Sci. 2011;52(6):2905-2910. doi:10.1167/iovs.10-6712
74. Niibe K, Kawamura Y, Araki D, Morikawa S, Miura K, Suzuki S, Shimmura S, Sunabori T, Mabuchi Y, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y. Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS One. 2011;6(3):e17610. doi:10.1371/journal.pone.0017610
75. Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011;52(1):427-433. doi:10.1167/iovs.10-5807
76. Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Shimmura S, Masutomi K, Tsubota K. Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients. Mol Vis. 2011;17:1397-1404.
77. Kawakita T, Higa K, Shimmura S, Tomita M, Tsubota K, Shimazaki J. Fate of corneal epithelial cells separated from limbus in vivo. Invest Ophthalmol Vis Sci. 2011;52(11):8132-8137. doi:10.1167/iovs.11-7667
78. Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K. Four cases of corneal perforation in patients with chronic graft-versus-host disease. Mol Vis. 2011;17:598-606.
79. Higa K, Takeshima N, Moro F, Kawakita T, Kawashima M, Demura M, Shimazaki J, Asakura T, Tsubota K, Shimmura S. Porous Silk Fibroin Film as a Transparent Carrier for Cultivated Corneal Epithelial Sheets. J Biomater Sci. 2011;22(16):2261-2276. doi:10.1163/156856211X562723
80. Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Zheng X, Shiraishi A, Ohashi Y, Inatomi T, Tsubota K. Mathematical projection model of visual loss due to fuchs corneal dystrophy. Invest Ophthalmol Vis Sci. 2011;52(11):7888-7893. doi:10.1167/iovs.11-7788
81. Hatou S, Dogru M, Ibrahim OM, Wakamatsu T, Sato EA, Shimmura S, Negishi K, Tsubota K. The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren’s ulcer. Invest Ophthalmol Vis Sci. 2011;52(9):6680-6689. doi:10.1167/iovs.11-7666
82. Yamaguchi T, Negishi K, Yamaguchi K, Dogru M, Uchino Y, Shimmura S, Tsubota K. Comparison of anterior and posterior corneal surface irregularity in Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty. Cornea. 2010;29(10):1086-1090. doi:10.1097/ICO.0b013e3181d9f07a
83. Omoto M, Shimmura S, Hatou S, Ichihashi Y, Kawakita T, Tsubota K. Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency. Jpn J Ophthalmol. 2010;54(6):537-543. doi:10.1007/s10384-010-0870-1
84. Kubota M, Shimmura S, Miyashita H, Kawashima M, Kawakita T, Tsubota K. The anti-oxidative role of ABCG2 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51(11):5617-5622. doi:10.1167/iovs.10-5201
85. Kawashima M, Kawakita T, Okada N, Ogawa Y, Murat D, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K. Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats. Biochem Biophys Res Commun. 2010;397(4):724-728. doi:10.1016/j.bbrc.2010.06.050
86. Yuki K, Shimmura S, Shiba D, Tsubota K. End-stage glaucoma in Stevens-Johnson syndrome. Jpn J Ophthalmol. 2009;53(1):68-70. doi:10.1007/s10384-008-0610-8
87. Yamaguchi T, Negishi K, Yamaguchi K, Murat D, Uchino Y, Shimmura S, Tsubota K. Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty. J Cataract Refract Surg. 2009;35(4):688-694. doi:10.1016/j.jcrs.2008.12.029
88. Omoto M, Miyashita H, Shimmura S, Higa K, Kawakita T, Yoshida S, McGrogan M, Shimazaki J, Tsubota K. The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets. Invest Ophthalmol Vis Sci. 2009;50(5):2109-2115. doi:10.1167/iovs.08-2895
89. Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K. Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. Am J Pathol. 2009;175(6):2372-2381. doi:10.2353/ajpath.2009.090333
90. Morikawa S, Mabuchi Y, Niibe K, Suzuki S, Nagoshi N, Sunabori T, Shimmura S, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y. Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun. 2009;379(4):1114-1119. doi:10.1016/j.bbrc.2008.12.164
91. Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori T, Shimmura S, Miyawaki A, Nakagawa T, Suda T, Okano H, Matsuzaki Y. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med. 2009;206(11):2483-2496. doi:10.1084/jem.20091046
92. Ma X, Shimmura S, Miyashita H, Yoshida S, Kubota M, Kawakita T, Tsubota K. Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas. Invest Ophthalmol Vis Sci. 2009;50(6):2716-2721. doi:10.1167/iovs.08-3165
93. Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K. Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis. 2009;15:2751-2761.
94. Kawashima M, Kawakita T, Yoshida S, Shimmura S, Tsubota K. Nucleostemin as a possible progenitor marker of corneal epithelial cells. Mol Vis. 2009;15:1162-1168.
95. Kawashima M, Kawakita T, Shimmura S, Tsubota K, Shimazaki J. Characteristics of traumatic globe rupture after keratoplasty. Ophthalmology. 2009;116(11):2072-2076. doi:10.1016/j.ophtha.2009.05.011
96. Kawakita T, Shimmura S, Higa K, Espana EM, He H, Shimazaki J, Tsubota K, Tseng SC. Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets. Invest Ophthalmol Vis Sci. 2009;50(10):4611-4617. doi:10.1167/iovs.08-2894
97. Higa K, Shimmura S, Miyashita H, Kato N, Ogawa Y, Kawakita T, Shimazaki J, Tsubota K. N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro. Invest Ophthalmol Vis Sci. 2009;50(10):4640-4645. doi:10.1167/iovs.08-3199
98. Yuki K, Shimmura S, Shiba D, Tsubota K. Trabeculotomy for the treatment of glaucoma after Descemet stripping endothelial keratoplasty. Br J Ophthalmol. 2008;92(9):1299-1300. doi:10.1136/bjo.2008.141872
99. Uchino M, Schaumberg DA, Dogru M, Uchino Y, Fukagawa K, Shimmura S, Satoh T, Takebayashi T, Tsubota K. Prevalence of dry eye disease among Japanese visual display terminal users. Ophthalmology. 2008;115(11):1982-1988. doi:10.1016/j.ophtha.2008.05.022
100. Uchino M, Dogru M, Uchino Y, Fukagawa K, Shimmura S, Takebayashi T, Schaumberg DA, Tsubota K. Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students. Am J Ophthalmol. 2008;146(6):925-929.e2. doi:10.1016/j.ajo.2008.07.019
101. Tomita M, Shimmura S, Tsubota K, Shimazaki J. Postkeratoplasty atopic sclerokeratitis in keratoconus patients. Ophthalmology. 2008;115(5):851-856. doi:10.1016/j.ophtha.2007.07.036
102. Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H. Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. J Biol Chem. 2008;283(36):24561-24570. doi:10.1074/jbc.M802871200
103. Mochimaru H, Usui T, Yaguchi T, Nagahama Y, Hasegawa G, Usui Y, Shimmura S, Tsubota K, Amano S, Kawakami Y, Ishida S. Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci. 2008;49(5):2172-2177. doi:10.1167/iovs.07-1335
104. Miyashita H, Shimmura S, Higa K, Yoshida S, Kawakita T, Shimazaki J, Tsubota K. A novel NIH/3T3 duplex feeder system to engineer corneal epithelial sheets with enhanced cytokeratin 15-positive progenitor populations. Tissue Eng Part A. 2008;14(7):1275-1282. doi:10.1089/ten.tea.2007.0371
105. Kawakita T, Shimmura S, Hornia A, Higa K, Tseng SC. Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell. J Cell Mol Med. 2008;12(4):1303-1316. doi:10.1111/j.1582-4934.2008.00160.x
106. Igarashi T, Shimmura S, Yoshida S, Tonogi M, Shinozaki N, Yamane GY. Isolation of oral epithelial progenitors using collagen IV. Oral Dis. 2008;14(5):413-418. doi:10.1111/j.1601-0825.2007.01391.x
107. Uchino Y, Shimmura S, Miyashita H, Taguchi T, Kobayashi H, Shimazaki J, Tanaka J, Tsubota K. Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium. J Biomed Mater Res B Appl Biomater. 2007;81(1):201-206. doi:10.1002/jbm.b.30653
108. Shimazaki J, Higa K, Morito F, Dogru M, Kawakita T, Satake Y, Shimmura S, Tsubota K. Factors influencing outcomes in cultivated limbal epithelial transplantation for chronic cicatricial ocular surface disorders. Am J Ophthalmol. 2007;143(6):945-953. doi:10.1016/j.ajo.2007.02.043
109. Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H. SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007;303(2):591-600. doi:10.1016/j.ydbio.2006.12.022
110. Ogawa Y, Razzaque MS, Kameyama K, Hasegawa G, Shimmura S, Kawai M, Okamoto S, Ikeda Y, Tsubota K, Kawakami Y, Kuwana M. Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD. Invest Ophthalmol Vis Sci. 2007;48(3):1079-1086. doi:10.1167/iovs.06-0857
111. Miyashita H, Higa K, Kato N, Kawakita T, Yoshida S, Tsubota K, Shimmura S. Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro. Invest Ophthalmol Vis Sci. 2007;48(8):3586-3593. doi:10.1167/iovs.07-0130
112. Matsumoto Y, Dogru M, Sato EA, Katono Y, Uchino Y, Shimmura S, Tsubota K. The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. Mol Vis. 2007;13:1319-1326.
113. Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H, Tsubota K. Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci. 2007;48(4):1511-1517. doi:10.1167/iovs.06-0562
114. Higuchi A, Ueno R, Shimmura S, Suematsu M, Dogru M, Tsubota K. Albumin rescues ocular epithelial cells from cell death in dry eye. Curr Eye Res. 2007;32(2):83-88. doi:10.1080/02713680601111003
115. Higa K, Shimmura S, Kato N, Kawakita T, Miyashita H, Itabashi Y, Fukuda K, Shimazaki J, Tsubota K. Proliferation and Differentiation of Transplantable Rabbit Epithelial Sheets Engineered with or without an Amniotic Membrane Carrier. Invest Ophthalmol Vis Sci. 2007;48(2):597-604. doi:10.1167/iovs.06-0414
116. Dogru M, Kato N, Matsumoto Y, Tanaka Y, Akabane N, Shimmura S, Tsubota K, Shimazaki J. Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Curr Eye Res. 2007;32(10):863-870. doi:10.1080/02713680701625409
117. Den S, Shimmura S, Tsubota K, Shimazaki J. Impact of the descemet membrane perforation on surgical outcomes after deep lamellar keratoplasty. Am J Ophthalmol. 2007;143(5):750-754. doi:10.1016/j.ajo.2007.01.009
118. Yoshida S, Shimmura S, Nagoshi N, Fukuda K, Matsuzaki Y, Okano H, Tsubota K. Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea. Stem Cells. 2006;24(12):2714-2722. doi:10.1634/stemcells.2006-0275
119. Yoshida S, Shimmura S, Kawakita T, Miyashita H, Den S, Shimazaki J, Tsubota K. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci. 2006;47(11):4780-4786. doi:10.1167/iovs.06-0371
120. Uchino Y, Goto E, Takano Y, Dogru M, Shinozaki N, Shimmura S, Yagi Y, Tsubota K, Shimazaki J. Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency. Ophthalmology. 2006;113(7):1098-1101. doi:10.1016/j.ophtha.2006.01.077
121. Tomita M, Shimmura S, Tsubota K, Shimazaki J. Dacryoadenitis associated with Acanthamoeba keratitis. Arch Ophthalmol. 2006;124(9):1239-1242. doi:10.1001/archopht.124.9.1239
122. Shimmura S, Miyashita H, Uchino Y, Taguchi T, Kobayashi H, Shimazaki J, Tanaka J, Tsubota K. Microkeratome assisted deep lamellar keratoprosthesis. Br J Ophthalmol. 2006;90(7):826-829. doi:10.1136/bjo.2006.090624
123. Shimmura S, Miyashita H, Higa K, Yoshida S, Shimazaki J, Tsubota K. Proteomic analysis of soluble factors secreted by limbal fibroblasts. Mol Vis. 2006;12:478-484.
124. Shimazaki J, Konomi K, Shimmura S, Tsubota K. Ocular surface reconstruction for thermal burns caused by fireworks. Cornea. 2006;25(2):139-145. doi:10.1097/01.ico.0000179979.62024.47
125. Miyashita H, Shimmura S, Kobayashi H, Taguchi T, Asano-Kato N, Uchino Y, Kato M, Shimazaki J, Tanaka J, Tsubota K. Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium. J Biomed Mater Res B Appl Biomater. 2006;76(1):56-63. doi:10.1002/jbm.b.30325
126. Maruyama-Hosoi F, Shimazaki J, Shimmura S, Tsubota K. Changes Observed in Keratolimbal Allograft. Cornea. 2006;25(4):377-382. doi:10.1097/01.ico.0000213133.05739.0a
127. Kawashima M, Kawakita T, Den S, Shimmura S, Tsubota K, Shimazaki J. Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies. Am J Ophthalmol. 2006;142(2):304-309. doi:10.1016/j.ajo.2006.03.041
128. Higuchi A, Shimmura S, Takeuchi T, Suematsu M, Tsubota K. Elucidation of apoptosis induced by serum deprivation in cultured conjunctival epithelial cells. Br J Ophthalmol. 2006;90(6):760-764. doi:10.1136/bjo.2005.083892
129. Higa K, Shimmura S, Shimazaki J, Tsubota K. Ocular surface epithelial cells up-regulate HLA-G when expanded in vitro on amniotic membrane substrates. Cornea. 2006;25(6):715-721. doi:10.1097/01.ico.0000220666.27361.64
130. Den S, Shimizu K, Ikeda T, Tsubota K, Shimmura S, Shimazaki J. Association between meibomian gland changes and aging, sex, or tear function. Cornea. 2006;25(6):651-655. doi:10.1097/01.ico.0000220664.12027.66
131. Den S, Dogru M, Kato N, Tanaka Y, Shimmura S, Shimazaki J. Disseminated keratoconjunctival epitheliopathy in a patient with systemic lupus erythematosus. Br J Ophthalmol. 2006;90(8):1068-1070. doi:10.1136/bjo.2006.091010
132. Yoshida S, Shimmura S, Shimazaki J, Shinozaki N, Tsubota K. Serum-free spheroid culture of mouse corneal keratocytes. Invest Ophthalmol Vis Sci. 2005;46(5):1653-1658. doi:10.1167/iovs.04-1249
133. Shimmura S, Shimazaki J, Omoto M, Teruya A, Ishioka M, Tsubota K. Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics. Cornea. 2005;24(2):178-181. doi:10.1097/01.ico.0000147660.10984.c3
134. Shimmura S, Omoto M, Den S, Bissen-Miyajima H, Tsubota K, Shimazaki J. Microkeratome-assisted phacoemulsification. J Cataract Refract Surg. 2005;31(9):1699-1701. doi:10.1016/j.jcrs.2005.05.029
135. Shimmura S, Miyashita H, Konomi K, Shinozaki N, Taguchi T, Kobayashi H, Shimazaki J, Tanaka J, Tsubota K. Transplantation of corneal endothelium with Descemet’s membrane using a hyroxyethyl methacrylate polymer as a carrier. Br J Ophthalmol. 2005;89(2):134-137. doi:10.1136/bjo.2004.053523
136. Higa K, Shimmura S, Shimazaki J, Tsubota K. Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma. Cornea. 2005;24(2):206-212. doi:10.1097/01.ico.0000148408.82421.36
137. Higa K, Shimmura S, Miyashita H, Shimazaki J, Tsubota K. Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells. Exp Eye Res. 2005;81(2):218-223. doi:10.1016/j.exer.2005.02.007
138. Dogru M, Asano-Kato N, Tanaka M, Igarashi A, Shimmura S, Shimazaki J, Okada N, Takano Y, Fukagawa K, Tsubota K, Fujishima H. Ocular Surface and MUC5AC Alterations in Atopic Patients with Corneal Shield Ulcers. Curr Eye Res. 2005;30(10):897-908. doi:10.1080/02713680500305886
139. Shimmura S, Tadano K, Tsubota K. UV dose-dependent caspase activation in a corneal epithelial cell line. Curr Eye Res. 2004;28(2):85-92. doi:10.1076/ceyr.28.2.85.25304
140. Shimmura S, Ando M, Ishioka M, Shimazaki J, Tsubota K. Same-size donor corneas for myopic keratoconus. Cornea. 2004;23(4):345-349. doi:10.1097/01.ico.0000109968.41434.b0
141. Shimazaki J, Shinozaki N, Shimmura S, Holland EJ, Tsubota K. Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation. Transplantation. 2004;78(2):216-220. doi:10.1097/01.tp.0000127598.67975.d4
142. Shimazaki J, Shimmura S, Tsubota K. Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea. Ophthalmology. 2004;111(1):38-44. doi:10.1016/j.ophtha.2003.05.004
143. Konomi K, Shimazaki J, Shimmura S, Akabane N, Goto E, Tsubota K. Efficacy of core vitrectomy preceding triple corneal procedure. Br J Ophthalmol. 2004;88(8):1023-1025. doi:10.1136/bjo.2003.037419
144. Kobayashi H, Kato M, Taguchi T, Ikoma T, Miyashita H, Shimmura S, Tsubota K, Tanaka J. Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea. Mater Sci Eng C. 2004;24(5):729-735. doi:10.1016/j.msec.2004.02.004
145. Dogru M, Kaderli B, Gelisken O, Yucel A, Avci R, Goto E, Shimmura S, Shimazaki J, Tsubota K. Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus. Am J Ophthalmol. 2004;138(3):381-388. doi:10.1016/j.ajo.2004.05.006
146. Bissen-Miyajima H, Nakamura K, Kaido M, Shimmura S, Tsubota K. Role of the endothelial pump in flap adhesion after laser in situ keratomileusis. J Cataract Refract Surg. 2004;30(9):1989-1992. doi:10.1016/j.jcrs.2004.04.028
147. Shimmura S, Ueno R, Matsumoto Y, Goto E, Higuchi A, Shimazaki J, Tsubota K. Albumin as a tear supplement in the treatment of severe dry eye. Br J Ophthalmol. 2003;87(10):1279-1283. doi:10.1136/bjo.87.10.1279
148. Shimmura S, Shimazaki J, Tsubota K. Therapeutic deep lamellar keratoplasty for cornea perforation. Am J Ophthalmol. 2003;135(6):896-897. doi:10.1016/s0002-9394(03)00150-7
149. Shimmura S, Ohashi Y, Shiroma H, Shimazaki J, Tsubota K. Corneal opacity and cataract: triple procedure versus secondary approach. Cornea. 2003;22(3):234-238. doi:10.1097/00003226-200304000-00008
150. Shimmura S, Igarashi R, Yaguchi H, Ohashi Y, Shimazaki J, Tsubota K. Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers. Am J Ophthalmol. 2003;135(5):613-619. doi:10.1016/s0002-9394(02)02242-4
151. Shimmura S, Doillon CJ, Griffith M, Nakamura M, Gagnon E, Usui A, Shinozaki N, Tsubota K. Collagen-poly(N-isopropylacrylamide)-based membranes for corneal stroma scaffolds. Cornea. 2003;22(7 Suppl):S81-S88. doi:10.1097/00003226-200310001-00014
152. Shimazaki J, Kosaka K, Shimmura S, Tsubota K. Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium. Ophthalmology. 2003;110(1):119-124. doi:10.1016/S0161-6420(02)01540-X
153. Mori A, Shimazaki J, Shimmura S, Fujishima H, Oguchi Y, Tsubota K. Disposable eyelid-warming device for the treatment of meibomian gland dysfunction. Jpn J Ophthalmol. 2003;47(6):578-586. doi:10.1016/j.jjo.2003.08.006
154. Asano-Kato N, Toda I, Shimmura S, Noda-Tsuruya T, Fukagawa K, Yoshinaga M, Matsukawa A, Tsubota K. Detection of neutrophils and possible involvement of interleukin-8 in diffuse lamellar keratitis after laser in situ keratomileusis. J Cataract Refract Surg. 2003;29(10):1996-2000. doi:10.1016/S0886-3350(03)00474-0
155. Tsubota K, Shimmura S, Shinozaki N, Holland EJ, Shimazaki J. Clinical application of living-related conjunctival-limbal allograft. Am J Ophthalmol. 2002;133(1):134-135. doi:10.1016/S0002-9394(01)01264-9
156. Takahashi H, Sakamoto A, Takahashi R, Ohmura T, Shimmura S, Ohara K. Free radicals in phacoemulsification and aspiration procedures. Arch Ophthalmol. 2002;120(10):1348-1352. doi:10.1001/archopht.120.10.1348
157. Shimazaki J, Shimmura S, Tsubota K. Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy). Cornea. 2002;21(2):177-180. doi:10.1097/00003226-200203000-00009
158. Shimazaki J, Shimmura S, Ishioka M, Tsubota K. Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty. Am J Ophthalmol. 2002;134(2):159-165. doi:10.1016/S0002-9394(02)01524-7
159. Shimazaki J, Aiba M, Goto E, Kato N, Shimmura S, Tsubota K. Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders. Ophthalmology. 2002;109(7):1285-1290. doi:10.1016/S0161-6420(02)01018-8
160. Higuchi A, Shimmura S, Ishii M, Aburatani H, Tsubota K. Serum- and serum deprivation-induced transcriptional profiles of cultured conjunctival epithelial cells. Adv Exp Med Biol. 2002;506(Pt A):673-676.
161. Goto E, Shimazaki J, Monden Y, Takano Y, Yagi Y, Shimmura S, Tsubota K. Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction. Ophthalmology. 2002;109(11):2030-2035. doi:10.1016/S0161-6420(02)01254-2
162. Goto E, Monden Y, Takano Y, Mori A, Shimmura S, Shimazaki J, Tsubota K. Treatment of non-inflamed obstructive meibomian gland dysfunction by an infrared warm compression device. Br J Ophthalmol. 2002;86(12):1403-1407. doi:10.1136/bjo.86.12.1403
163. Shimmura S, Shimazaki J, Ohashi Y, Tsubota K. Anti-inflammatory effects of amniotic membrane transplantation in ocular surface disorders. Cornea. 2001;20(4):408-413. doi:10.1097/00003226-200105000-00015
164. Shimazaki J, Maruyama F, Shimmura S, Fujishima H, Tsubota K. Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty. Cornea. 2001;20(2):149-152. doi:10.1097/00003226-200103000-00008
165. Miyoshi T, Fukagawa K, Shimmura S, Fujishima H, Takano Y, Takamura E, Tsubota K, Saito H, Oguchi Y. Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage. Cornea. 2001;20(7):743-747. doi:10.1097/00003226-200110000-00016
166. Ishioka M, Shimmura S, Yagi Y, Tsubota K. Pterygium and dry eye. Ophthalmologica. 2001;215(3):209-211. doi:10.1159/000050868
167. Hanada K, Shimazaki J, Shimmura S, Tsubota K. Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera. Am J Ophthalmol. 2001;131(3):324-331. doi:10.1016/S0002-9394(00)00779-7
168. Goto E, Shimmura S, Shimazaki J, Tsubota K. Treatment of superior limbic keratoconjunctivitis by application of autologous serum. Cornea. 2001;20(8):807-810. doi:10.1097/00003226-200111000-00005
169. Shimmura S, Matsumoto K, Yaguchi H, Okuda T, Miyajima S, Negi A, Shimazaki J, Tsubota K. Acidic electrolyzed water in the disinfection of the ocular surface. Exp Eye Res. 2000;70(1):1-6. doi:10.1006/exer.1999.0782
170. Shimmura S, Ishioka M, Hanada K, Shimazaki J, Tsubota K. Telomerase activity and p53 expression in pterygia. Invest Ophthalmol Vis Sci. 2000;41(6):1364-1369.
171. Shimmura S, Ando M, Shimazaki J, Tsubota K. Complications with one-piece lamellar kerato-limbal grafts for simultaneous limbal and corneal pathologies. Cornea. 2000;19(4):439-442. doi:10.1097/00003226-200007000-00009
172. Shimazaki S, Shimmura S, Fujishima H, Tsubota K. Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome. Ophthalmology. 2000;107(8):1518-1523. doi:10.1016/S0161-6420(00)00244-9
173. Shimazaki J, Hanada K, Yagi Y, Yamagami J, Ishioka M, Shimmura S, Tsubota K. Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol v 0. 12% unoprostone. Br J Ophthalmol. 2000;84(11):1250-1254. doi:10.1136/bjo.84.11.1250
174. Nakamura K, Bissen-Miyajima H, Shimmura S, Tsubota K. Clinical application of Er:YAG laser for the treatment of pterygium. Ophthalmic Surg Lasers. 2000;31(1):8-12.
175. Ishioka M, Shimazaki J, Yamagami J, Fujishima H, Shimmura S, Tsubota K. Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. Br J Ophthalmol. 2000;84(7):714-717. doi:10.1136/bjo.84.7.714
176. Fukagawa K, Nakajima T, Saito H, Tsubota K, Shimmura S, Natori M, Hirai K. IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells. Int Arch Allergy Immunol. 2000;121(2):144-150. doi:10.1159/000024340
177. Tsubota K, Satake Y, Kaido M, Shinozaki N, Shimmura S, Bissen-Miyajima H, Shimazaki J. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med. 1999;340(22):1697-1703. doi:10.1056/NEJM199906033402203
178. Tsubota K, Monden Y, Yagi Y, Goto E, Shimmura S. New treatement of dry eye. The effect of calcium ointment through eyelid skin delivery. Br J Ophthalmol. 1999;83(6):767-770. doi:10.1136/bjo.83.6.767
179. Tsubota K, Kaido M, Yagi Y, Fujihara T, Shimmura S. Diseases associated with ocular surface abnormalities: The importance of reflex tearing. Br J Ophthalmol. 1999;83(1):89-91. doi:10.1136/bjo.83.1.89
180. Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 1999;106(10):1984-1989. doi:10.1016/S0161-6420(99)90415-X
181. Tsubota K, Goto E, Fujita H, Ono M, Inoue H, Saito I, Shimmura S. Treatment of dry eye by autologus serum application in Sjogren’s Syndrome. Br J Ophthalmol. 1999;83(4):390-395. doi:10.1136/bjo.83.4.390
182. Tsubota K, Fukagawa K, Fujihara T, Shimmura S, Saito I, Saito K, Takeuchi T. Regulation of HLA DR expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci. 1999;40(1):28-34.
183. Takano Y, Fukagawa K, Shimmura S, Tsubota K, Oguchi Y, Saito H. IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells. Br J Ophthalmol. 1999;83(9):1074-1076. doi:10.1136/bjo.83.9.1074
184. Shimmura S, Shimazaki J, Tsubota K. Results of a population -based questionnaire on the symptoms and lifestyles associated with dry eye. Cornea. 1999;18(4):408-411. doi:10.1097/00003226-199907000-00009
185. Shimmura S, Masumizu T, Urayama K, Shimazaki J, Bissen-Miyajima H, Tsubota K. Excimer laser-induced hydroxyl radical formation and keratocyte death in vitro. Invest Ophthalmol Vis Sci. 1999;40(6):1245-1249.
186. Shimazaki J, Shimmura S, Yamato K, Tsubota K. Morphology and barrier function of the corneal epithelium following penetrating keratoplasty: association with original diseases, tear function, and suture removal. Cornea. 1999;18(5):559-564. doi:10.1097/00003226-199909000-00007
187. Shimazaki J, Kaido M, Shinozaki N, Shimmura S, Munkhbat B, Hagihara M, Tsuji K, Tsubota K. Evidence of long-term survival of donor-derived cells after limbal allograft transplantation. Invest Ophthalmol Vis Sci. 1999;40(8):1664-1668.
188. Nakamura K, Bissen-Miyajima H, Arai H, Toda I, Hori Y, Shimmura S, Tsubota K. Iatrogenic cataract after laser-assisted in situ keratomileusis. Am J Ophthalmol. 1999;128(4):507-509. doi:10.1016/S0002-9394(99)00216-7
189. Fukagawa K, Nakajima T, Tsubota K, Shimmura S, Saito H, Hirai K. Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. J Allergy Clin Immunol. 1999;103(6):1220-1221. doi:10.1016/S0091-6749(99)70267-3
190. Bissen-Miyajima H, Shimmura S, Tsubota K. Thermal effect on corneal incisions with different ultrasonic tips. J Cataract Refract Surg. 1999;25(1):60-64. doi:10.1016/S0886-3350(99)80058-2
191. Shimmura S, Shinozaki N, Fukagawa K, Shimazaki J, Tsubota K. Real-time telemedicine in the clinical assessment of the ocular surface. Am J Ophthalmol. 1998;125(3):388-390. doi:10.1016/S0002-9394(98)00344-7
192. Shimmura S, Shimoyama M, Hojo M, Urayama K, Tsubota K. Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin. Invest Ophthalmol Vis Sci. 1998;39(8):1346-1351.
193. Shimmura S, Matsumoto K, Goto E, Saito K, Takeuchi T, Miyajima S, Negi A, Tsubota K. Lecithin-bound superoxide dismutase in the prevention of neutrophil-induced damage of corneal tissue. Invest Ophthalmol Vis Sci. 1998;39(1):30-35.
194. Shimmura S, Goto E, Shimazaki J, Tsubota K. Viscosity-dependent fluid dynamics of eyedrops on the ocular surface. Am J Ophthalmol. 1998;125(3):386-388. doi:10.1016/S0002-9394(98)00343-5
195. Shimazaki J, Yang HY, Shimmura S, Tsubota K. Terrien’s marginal degeneration associated with erythema elevatum diutinum. Cornea. 1998;17(3):342-344. doi:10.1097/00003226-199805000-00017
196. Shimazaki J, Shimmura S, Tsubota K. Intraoperative versus postoperative suture adjustment after penetrating keratoplasty. Cornea. 1998;17(6):590-594. doi:10.1097/00003226-199811000-00014
197. Shimazaki J, Goto E, Ono M, Shimmura S, Tsubota K. Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology. 1998;105(8):1485-1488. doi:10.1016/S0161-6420(98)98048-7
198. Shimoyama M, Shimmura S, Tsubota K, Oguchi Y. Suppression of nuclear factor kappa B and CD 18 mediated leukocyte adhesion to the corneal endothelium by dexamethasone. Invest Ophthalmol Vis Sci. 1997;38(11):2427-2431.
199. Shimmura S, Yang HY, Bissen-Miyajima H, Shimazaki J, Tsubota K. Posterior corneal protrusion following PRK. Cornea. 1997;16(6):686-688. doi:10.1097/00003226-199711000-00017
200. Shimmura S, Tsubota K. Ultraviolet B-induced mitochondrial dysfunction is associated with decreased cell detachment of corneal epithelial cells in vitro. Invest Ophthalmol Vis Sci. 1997;38(3):620-626.
201. Shimmura S, Shinozaki N, Fukagawa K, Tsubota K. Telemedicine in the follow-up of corneal transplant patients. J Telemed Telecare. 1997;3(4):227-228. doi:10.1258/1357633971931320
202. Fukagawa K, Saito H, Tsubota K, Shimmura S, Tachimoto H, Akasawa A, Oguchi Y. RANTES production in a conjunctival epithelial cell line. Cornea. 1997;16(5):564-570.
203. Shimmura S, Suematsu M, Shimoyama M, Tsubota K, Oguchi Y, Ishimura Y. Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin. Exp Eye Res. 1996;63(5):519-526. doi:10.1006/exer.1996.0125
204. Shimmura S, Ono M, Shinozaki K, Toda I, Takamura E, Mashima Y, Tsubota K. Sodium hyaluronate eyedrops in the treatment of dry eyes. Br J Ophthalmol. 1995;79(11):1007-1011. doi:10.1136/bjo.79.11.1007
205. Shimmura S, Tsubota K, Oguchi Y, Fukumura D, Suematsu M, Tsuchiya M. Oxiradical-dependent photoemission induced by a phacoemulsification probe. Invest Ophthalmol Vis Sci. 1992;33(10):2904-2907.