相談眼科医

I. Introduction: Defining Cornea Limbal Stem Cell Deficiency ( LSCD): The Failure of Corneal Renewal The cornea, the transparent outer layer of the eye, requires constant renewal to maintain its smooth, clear surface and optimal visual function. This renewal process is governed by a specialized population of cells located at the corneo-scleral junction. Limbal Stem Cell Deficiency (LSCD) , therefore, is a severe ocular surface disease characterized by the failure of these ess

I. Introduction: Corneal Transplantation vs Endothelial Cell Injection Therapy For patients suffering from corneal edema due to endothelial failure, two primary strategies exist: the established method of corneal transplantation  and the cutting-edge approach of cell therapy . The debate of corneal transplant vs cell therapy  is fundamentally a comparison between tissue replacement  (transplantation) and cellular regeneration  (injection therapy). While transplantation, part

I. Introduction: The Cost of Regeneration: Understanding Neltependocel Pricing Neltependocel (Vyznova, cultivated corneal endothelial cell injection) is a revolutionary regenerative therapy offering a cure for corneal edema (Bullous Keratopathy) . While the immense value of this treatment—overcoming donor scarcity and providing a low-invasive cure—is clear, patients must understand the neltependocel cost . The total financial outlay for this treatment, encompassing both the

I. Introduction: The Global Shortage Behind the Cornea Donor Waiting List Corneal transplantation is a miraculous procedure capable of restoring sight to those blinded by corneal diseases such as Bullous Keratopathy , Fuchs' Endothelial Dystrophy , advanced Keratoconus , and severe post-infectious or traumatic Corneal Scarring . Yet, this success is consistently overshadowed by a critical constraint: the global shortage of viable donor corneas. The existence of a protracted c

I. Introduction: Beyond Transplantation to Cell Replacement Therapy for Corneal Edema Chronic corneal edema results from the irreversible failure of the corneal endothelium—the non-regenerative cell layer responsible for maintaining corneal clarity. While traditional corneal transplantation (DMEK/DSAEK) is the established treatment, it faces inherent challenges: a chronic global shortage of donor tissue and the lifelong risk of immune rejection. The concept of cell therapy